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Relevant academic research and scientific papers

A novel lipase enzyme panel exhibiting superior activity and selectivity over lipase B from Candida antarctica for the kinetic resolution of secondary alcohols

A novel, commercially available lipase enzyme panel performing kinetic bioresolutions of a number of secondary alcohols is reported. The secondary alcohols that have been chosen are known from the literature to be particularly challenging substrates to resolve. Following initial screening, four co-solvents were investigated for each lead enzyme in an effort to assess their tolerance to common organic solvents. The superiority of these novel enzymes over lipase B from Candida antarctica (CALB) has been demonstrated.

Novel Intermediate of L-Cloperastine and Preparation Method Thereof

The present invention refers to pharmaceutically useful as well as novel intermediates of [...][...] -L (cloperastine) manufacturing method relates to and, more specifically a device with structure of formula 1 L- [...] intermediates manufacturing method of using enzymes relates to. Formula 1 , The, R the C1-C3 copyright 2000. (by machine translation)

Kinetic resolution of diarylmethanols using a mutated variant of lipase CALB

An enzymatic kinetic resolution of diarylmethanols via acylation has been developed. This was achieved by the use of a mutated variant of CALB that accepts larger substrates compared to the wild type. By the use of diarylmethanols with two differently sized aryl groups, enantioselective transformations were achieved. A larger size-difference led to a higher enantioselectivity. In addition, substrates with electronically different aryl groups, such as phenyl and pyridyl, also gave an enantioselective reaction. The highest E value was observed with a substrate where steric and electronic effects were combined.