80774-13-6

Basic information

• Product Name: 2-methyl-6-phenylimidazo<2,1-b>-1,3,4-thiadiazole-5-carboxaldehyde
• Synonyms: 2-methyl-6-phenylimidazo<2,1-b>-1,3,4-thiadiazole-5-carboxaldehyde
• CAS NO: 80774-13-6
• Molecular Weight: 243.289
• Mol File: 80774-13-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-methyl-6-phenylimidazo<2,1-b>-1,3,4-thiadiazole-5-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-6-phenylimidazo<2,1-b>-1,3,4-thiadiazole-5-carboxaldehyde(80774-13-6)
• EPA Substance Registry System: 2-methyl-6-phenylimidazo<2,1-b>-1,3,4-thiadiazole-5-carboxaldehyde(80774-13-6)

Safety Data

• Hazardous Substances Data: 80774-13-6(Hazardous Substances Data)

Upstream product

• 106833-39-0 5-methyl-3-(2-oxo-2-phenylethyl)-1,3,4-thiadiazol-2(3H)-iminium bromide 
• 70-11-1 α-bromoacetophenone 
• 57772-03-9 2-methyl-6-phenylimidazo[2,1-b]-1,3,4-thiadiazole 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 80774-47-6 N-[β-(2-Methyl-6-phenylimidazo[2,1-b]-1,3,4-thiadiazol-5-yl)]-propenoylpyrrolidine 
• 158530-54-2 (E)-2-methyl-6-phenylimidazo<2,1-b>-1,3,4-thiadiazole-5-carboxaldehyde dimethylaminoacetohydrazone 

Relevant articles and documents

Synthesis of imidazothiadiazole-benzimidazole conjugates as mitochondrial apoptosis inducers

A series of imidazothiadiazole-benzimidazole conjugates (3a-z) were synthesized and evaluated for their cytotoxic activity against a set of four selected human cancer cell lines. Amongst them, compounds 3b and 3y exhibited significant antiproliferative activity in ME-180 (cervical) cell line. Flow cytometric analysis showed that these two compounds arrested the cell cycle in the G0/G1 phase leading to the loss of mitochondrial membrane potential followed by apoptotic cell death. Further, Hoechst 33258 staining, DNA fragmentation assay, Annexin V staining assay and caspase-3 also suggested that 3b and 3y induced cell death by apoptosis. Docking studies revealed that compound 3b binds to the Gly142, Phe101, Asn140 and Arg143 on B-cell lymphoma 2 (Bcl-2) proteins and inhibition of Bcl-2 protein could be the possible mechanism of action for these compounds.