80777-36-2

Upstream product

• 2719-23-5 2-acetamidothiazole 
• 80777-35-1 2-dichloromethyl-8-trifluoromethyl-4H-3,1-benzoxazin-4-one 
• 58199-16-9 ethyl 3-oxo-3-(thiazol-2-ylamino)propanoate 
• 97817-18-0 ethyl 2-[(2,2-dichloro-1-oxoethyl)amino]-β-oxo-α-[(2-thiazolylamino)-carbonyl]-3-(trifluoromethyl)-benzene-propanoate 
• 313-12-2 2-amino-3-(trifluoromethyl)benzoic acid 

Relevant academic research and scientific papers

Alkyl β-oxo-benzenepropanoates

Novel alkyl β-oxo-benzenepropanoates of the formula STR1 wherein X is in the 5-,6-,7- or 8-position and is selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 4 carbon atoms, CF3 --, CF3/s

New Route to N-Aryl and N-Heteroaryl Derivatives of 4-Hydroxy-3-quinolinecarboxamides

The synthesis of N-aryl and N-heteroaryl substituted 4-hydroxy-3-quinolinecarboxamides 1 is described.The attack of dianions 12 of N-aryl substituted acetamides on the C-4 carbonyl of 4H-3,1-benzoxazin-4-ones 11 gave rise to ketoamides 13, which smoothly cyclized in the presence of bases to afford quinolinecarboxamides 1.By this method, a large number of 2-substituted 4-hydroxyquinolinecarboxamides can be prepared.

Analgesic 4-hydroxy-3-quinolinecarboxamides

Novel compounds of the formula STR1 wherein X is in the 5,6,7 or 8 position and is selected from the group consisting of hydrogen, halogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 4 carbon atoms, CF3 O--, CF3 S-- and CF3/s