80789-77-1

Usage

Uses

Used in Analytical Chemistry:
1-NITRONAPHTHALENE-D7 is utilized as a stable isotope internal standard in analytical chemistry methods. It aids in the accurate quantification and detection of 1-nitronaphthalene and related compounds, enhancing the reliability and precision of analytical results.
Used in Mass Spectrometry:
In mass spectrometry, 1-NITRONAPHTHALENE-D7 is employed to provide insights into the structure and behavior of the compound. The presence of deuterium can offer valuable information that assists in the identification and analysis of the compound.
Used in Nuclear Magnetic Resonance (NMR) Spectroscopy:
1-NITRONAPHTHALENE-D7 is also used in NMR spectroscopy, where the deuterium atoms contribute to a clearer understanding of the compound's molecular structure and dynamics, facilitating detailed studies of its properties and interactions.

Upstream product

• 1146-65-2 naphthalene-d8 

Downstream Products

• 78832-53-8 [D]₇-1-naphthylamine 

Relevant academic research and scientific papers

Free-Amine-Directed Iridium-Catalyzed C?H Bond Activation and Cyclization of Naphthalen-1-amines with Diazo Compounds Leading to Naphtho[1,8-bc]pyridines

Iridium-catalyzed C?H activation and cyclization of naphthalen-1-amines with diazo compounds leading to naphtho[1,8-bc]pyridines have been developed. Different from the previous free-amine-directed C?H functionalization with diazo compounds that relied on the coordination of lone pair electrons or in situ formation of imine, this transformation passes through a five-membered iridacycle intermediate containing an N?Ir σ-bond. It offers an alternative approach for the synthesis of useful diverse naphtho[1,8-bc]pyridine derivatives in mild conditions. (Figure presented.).

Cobalt-Catalyzed Direct Carbonylative Synthesis of Free (NH)-Benzo[ cd]indol-2(1 H)-ones from Naphthylamides

A cobalt-catalyzed C-H carbonylation of naphthylamides for the synthesis of benzo[cd]indol-2(1H)-one scaffolds has been developed. The reaction employs a traceless directing group and uses benzene-1,3,5-triyl triormate as the CO source, affording various free (NH)-benzo[cd]indol-2(1H)-ones in moderate to high yields (up to 88%). Using this protocol, the total synthesis of BET bromodomain inhibitors A and B was accomplished as well.

Electrochemical ruthenium-catalyzed alkyne annulations by C-H/Het-H activation of aryl carbamates or phenols in protic media

Electrooxidative peri-C-H activation was accomplished by versatile ruthenium(ii) catalysis in terms of C-H/N-H and C-H/O-H functionalization. Thus, alkyne annulations proved viable with ample scope by organometallic C-H activation. The sustainable electrocatalysis exploited electricity, thereby avoiding the use of toxic transition metals as sacrificial oxidants. The robust ruthenium(ii)-electrocatalysis was operative in a protic alcohol/H2O reaction medium with excellent levels of position-, regio- and chemo-selectivity.

C8-H bond activation vs. C2-H bond activation: From naphthyl amines to lactams

Pd-catalyzed selective amine-oriented C8-H bond functionalization/N-dealkylative carbonylation of naphthyl amines has been achieved. The amine group from dealkylation is proposed to be the directing group for promoting this process. It represents a straightforward and easy method to access various biologically important benzo[cd]indol-2(1H)-one derivatives.

Copper-mediated dehydrogenative biaryl coupling of naphthylamines and 1,3-azoles

A copper-mediated dehydrogenative biaryl cross-coupling of naphthylamines and 1,3-azoles has been developed. The key to its success is the introduction of N,N-bidentate coordination system based on the picolinamide directing group. The reaction proceeds s