80813-10-1

Usage

Structure

A phenyl group attached to a tetrahydro-2H-pyran ring with an acetic acid group

Classification

A derivative of tetrahydro-2H-pyran

Usage

A building block for the synthesis of various pharmaceuticals and bioactive compounds in medicinal chemistry research

Unique chemical reactivity

Provided by the combination of the phenyl group and the tetrahydro-2H-pyran ring

Potential pharmacological properties

Makes it a promising candidate for the development of new therapeutic agents.

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 33451-54-6 ethyl 2-cyano-2-(dihydro-2H-pyran-4(3H)-ylidene)acetate 
• 80813-09-8 cyano(4-phenyltetrahydropyran-4-yl)acetate d'ethyle 

Downstream Products

• 1581258-43-6 2-chloro-6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazine 
• 1542134-82-6 2-(4-phenyltetrahydro-2H-pyran-4-yl)ethanol 
• 1581258-24-3 3-(6-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethoxy)pyrazin-2-yl)benzonitrile 
• 1581258-11-8 6-(3-methoxyphenyl)-N-(2-(4-phenyltetrahydro-2H-pyran-4-yl)ethyl)pyrazin-2-amine 

Relevant academic research and scientific papers

TETRAHYDROPYRAN-4-YLETHYLAMINO- OR TETRAHYDROPYRANYL-4-ETHYLOXY-PYRIMIDINES OR -PYRIDAZINES AS ISOPRENYLCYSTEINCARBOXYMETHYL TRANSFERASE INHIBITORS

A compound of formula (I): wherein: R1 is selected from: (i) phenyl, optionally substituted by one fluoro group; (ii) thienyl; (iii) furanyl; (iv) C1-4 alkyl; and (v) H; R2 is selected from: (II), R3 is selected from: (III), X is selected from NH and O; R4 is selected from phenyl, a 5-membered heteroaryl or a 6-membered heteroaryl, all of which are optionally substituted by one or more substituents selected from the group consisting of: methyl, methoxy, trifluoromethyl, trifluoromethoxy, cyano, fluoro, -OC2H4OMe, and pyrazolyl.

CHIMIE ORGANOMETALLIQUE. XXII. SYNTHESE D'ARENES SUBSTITUES PAR ADDITION D'UN NUCLEOPHILE A UN ARENE CHROME TRICARBONYLE PUIS PAR DECOMPLEXATION OXYDANTE DU METAL

The product distribution obtained in addition reactions of -CH(CH3)CN to an arenechromium tricarbonyl is studied.The major product obtained after oxidative removal of the metal corresponds to nucleophilic addition on an arene carbon atom which is in an eclipsed position with respect to the carbonyl group of the Cr(CO)3 unit of the most stable conformer.The synthesis of the corresponding acid represents an example of arenechromium tricarbonyl chemistry applied to synthesis of an organic compound having pharmaceutical properties and which by classical methods could only be synthesized via a multi step process.