808132-23-2Relevant academic research and scientific papers
Myxopyronin B analogs as inhibitors of RNA polymerase, synthesis and biological evaluation
Doundoulakis, Thomas,Xiang, Alan X.,Lira, Ricardo,Agrios, Konstantinos A.,Webber, Stephen E.,Sisson, Wes,Aust, Robert M.,Shah, Amit M.,Showalter, Richard E.,Appleman, James R.,Simonsen, Klaus B.
, p. 5667 - 5672 (2007/10/03)
A series of myxopyronin B analogs has been prepared via a convergent synthetic route and were tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against E. coli and S. aureus. A series of myxopyronin B analogs has been prepared via a convergent synthetic route and were tested for in vitro inhibitory activity against DNA-dependent RNA polymerase and antibacterial activity against E. coli and S. aureus. The parent lead compound proved to be very sensitive to even small changes. Only the achiral desmethyl myxopyronin B (1a) provided enhanced potency.
