478190-05-5

Upstream product

• 1129-28-8 3-methoxycarbonylbenzyl bromide 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 82072-22-8 3-hydroxymethylbenzyl bromide 
• 626-18-6 1,3-dimethanol benzene 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 81805-53-0 3-(tert-Butyldimethylsiloxymethyl)benzyl Alcohol 

Downstream Products

• 808132-59-4 3-{2-[5-((2E,4E)-2,5-Dimethyl-nona-2,4-dienoyl)-4-hydroxy-6-oxo-6H-pyran-2-yl]-propyl}-benzoic acid methyl ester 
• 808132-23-2 3-[2-(4-hydroxy-6-oxo-5-propionyl-6H-pyran-2-yl)-propyl]-benzoic acid methyl ester 
• 808132-55-0 4-hydroxy-6-[2-(3-hydroxymethyl-phenyl)-1-methyl-ethyl]-3-propionyl-pyran-2-one 
• 808132-57-2 3-[2-(4-hydroxy-6-oxo-5-propionyl-6H-pyran-2-yl)-propyl]-benzaldehyde 
• 808132-21-0 6-{2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-1-methyl-ethyl}-4-hydroxy-3-propionyl-pyran-2-one 
• 478190-30-6 4-[2-(3-tert-butyldimethylsilyloxymethylbenzyloxyl)benzyl]-3-(β-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazole 

Relevant academic research and scientific papers

AMINOAZOLE DERIVATIVE

A compound, represented by the following formula or a medically acceptable salt thereof, having an effect of regulating the activity of an androgen receptor. In the formula, X represents S, O; Z represents (Ra)n-A- (CR13R14)0-1—(CR11R12)0-1; A represents aryl, heteroaryl; R1 represents alkyl, cycloalkyl, alkenyl, alkynyl, alkoxyalkyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl; R2 represents hydrogen, halogen, alkyl, cycloalkyl, phenyl; R3 represents hydrogen, halogen, alkyl, cycloalkyl, alkoxyalkyl, alkenyl, alkynyl, cycloalkenyl, aryl, arylalkyl, heterocycle, heterocyclic alkyl, acyl, cycloalkylcarbonyl, benzoyl, spiroalkyl, adamantyl, silyl, R31R32NCO—; R4 and R5 represent hydrogen, halogen, alkyl, phenyl, and cycloalkyl.

EP4 antagonists number

We provide compounds given by Formula I, which is shown in FIG. 3, or pharmaceutically acceptable salts thereof, as well as formulations thereof and methods of use of those compounds and formulations for treatment of cancer.

METHOD OF CONTROLLING LACTATE PRODUCTION WITH PIPERDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula: and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.

PIPERIDINE-DIONE DERIVATIVES

The invention provides novel compounds having the general formula (I) and tautomers and pharmaceutically acceptable salts thereof, wherein A1, A2, A3, A4, R1, R4, R5, R6, R7 and R8 are as defined herein, compositions including the compounds and methods of using the compounds.