808133-98-4

Upstream product

• 89978-56-3 1-bromo-4-methoxy-2-methyl-5-nitro-benzene 
• 90326-61-7 5-bromo-2-methoxy-4-methyl benzoic acid 
• 39503-58-7 methyl 5-bromo-2-methoxy-4-methylbenzoate 
• 50-85-1 2-hydroxy-p-toluic acid 
• 27060-75-9 4-bromo-3-methylanisole 
• 808133-96-2 5-bromo-2-methoxy-4-methylbenzamide 
• 182500-28-3 4-bromo-5-methyl-2-nitrophenol 

Downstream Products

• 808134-00-1 5-bromo-2-methoxy-4-methylbenzenesulfonyl chloride 
• 5456-94-0 2,4-dibromo-5-methylanisole 

Relevant academic research and scientific papers

cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

INHIBITORS OF PAPILLOMA VIRUS

The use of a compound of formula (II): or its enantiomers or diastereoisomers thereof, or salts or pharmaceutically-acceptable esters thereof, in the treatment or prevention of a papilloma virus infection, particularly human papilloma virus in a mammal, wherein R11; X4; X5; X6; R13; R14; W; Z; Y; T; and R18 are defined herein. The present invention also provides novel compounds, pharmaceutical compositions and methods for using these compounds and compositions in the treatment or prevention of papilloma virus infection. More particularly, the present invention provides compounds, compositions and methods for inhibiting papilloma virus DNA replication by interfering with the E1-E2 protein-protein interaction essential for viral DNA replication.