808157-06-4Relevant academic research and scientific papers
MANUFACTURING PROCESS FOR (S)-PREGABALIN
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Page/Page column 14-15, (2012/05/20)
The present invention relates to a novel manufacturing process and novel intermediates useful in the synthesis of pharmaceutically active compounds of general formula (I) used for treatment of epilepsy, neuropathic pain, anxiety and social phobia. The invention describes preparation of enantiomerically pure (S)-Pregabalin from chiral pyrrolidin-2-one of formula (IV).
A convenient chemoenzymatic synthesis of (R)-(-) and (S)-(+)-homo-β- proline
Felluga, Fulvia,Gombac, Valentina,Pitacco, Giuliana,Valentin, Ennio
, p. 3323 - 3327 (2007/10/03)
Both enantiomers of the heterocyclic GABA analogue homo-β-proline (3-pyrrolidineacetic acid) were synthesized by a chemoenzymatic method involving the use of two enantiocomplementary enzymes in the disymmetric hydrolyses of 3-nitromethylglutaric acid diethyl ester.
