122442-01-7 Usage
Description
(R)-3-Pyrrolidineacetic acid HCl, a chiral molecule, is a chemical compound characterized by a pyrrolidine ring attached to an acetic acid group, with a hydrochloride salt. The (R)-enantiomer is the active form, known for its interactions with specific receptor systems in the brain, such as the GABA and nicotinic acetylcholine receptors. This makes it a significant compound of interest in the field of neuropharmacology. Furthermore, it has demonstrated potential as a cognition enhancer and is being studied for its therapeutic applications in conditions related to cognitive impairment and memory deficits.
Uses
Used in Pharmaceutical Industry:
(R)-3-Pyrrolidineacetic acid HCl is used as a pharmaceutical compound for its potential therapeutic effects on cognitive impairment and memory deficits. Its interaction with GABA and nicotinic acetylcholine receptors in the brain suggests its potential role in enhancing cognitive functions and treating related disorders.
Used in Neuropharmacology Research:
In the field of neuropharmacology, (R)-3-Pyrrolidineacetic acid HCl is utilized as a research tool to study the mechanisms of action and potential therapeutic applications related to its interaction with brain receptor systems. This includes exploring its effects on cognitive functions and the treatment of cognitive impairments.
Used in Cognitive Enhancement Applications:
(R)-3-Pyrrolidineacetic acid HCl is employed as a cognition enhancer, with ongoing research aimed at understanding its potential to improve memory and cognitive performance. Its ability to modulate brain receptor systems suggests it may have applications in enhancing cognitive abilities in various populations, including those with cognitive impairments or in need of cognitive support.
Check Digit Verification of cas no
The CAS Registry Mumber 122442-01-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,4,4 and 2 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 122442-01:
(8*1)+(7*2)+(6*2)+(5*4)+(4*4)+(3*2)+(2*0)+(1*1)=77
77 % 10 = 7
So 122442-01-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H11NO2.ClH/c8-6(9)3-5-1-2-7-4-5;/h5,7H,1-4H2,(H,8,9);1H/t5-;/m1./s1
122442-01-7Relevant articles and documents
A convenient chemoenzymatic synthesis of (R)-(-) and (S)-(+)-homo-β- proline
Felluga, Fulvia,Gombac, Valentina,Pitacco, Giuliana,Valentin, Ennio
, p. 3323 - 3327 (2007/10/03)
Both enantiomers of the heterocyclic GABA analogue homo-β-proline (3-pyrrolidineacetic acid) were synthesized by a chemoenzymatic method involving the use of two enantiocomplementary enzymes in the disymmetric hydrolyses of 3-nitromethylglutaric acid diethyl ester.
A convenient approach to diastereomerically pure 1,3,4-trisubstituted pyrrolidin-2-ones by intramolecular cyclisation of N-(2-alken-1-yl)amides mediated by Mn(III). An entry to both (R)- and (S)-3-pyrrolidineacetic acid
Galeazzi, Roberta,Mobbili, Giovanna,Orena, Mario
, p. 1069 - 1084 (2007/10/03)
The oxidative cyclisation of a series of either (S)-N-(2-alken-1-yl)-N-(1-phenyleth-1-yl)-acetoacetamides 5a-d and methoxycarbonylacetamides 6a-b, performed by using Mn(OAc)3 · 2H2O and Cu(OAc)2 · H2O in acetic
GABA Agonists and Uptake Inhibitors. Synthesis, Absolute Stereochemistry, and Enantioselectivity of (R)-(-)- and (S)-(+)-Homo-β-proline
Nielsen, Lone,Brehm, Lotte,Krogsgaard-Larsen, Povl
, p. 71 - 77 (2007/10/02)
The cyclic analogue of 4-aminobutyric acid (GABA), 3-pyrrolidineacetic acid (homo-β-proline), is a potent agonist at GABAA receptors, it interacts effectively with GABA-uptake mechanisms, and it is a moderately potent inhibitor of GABAB/s
