808168-96-9Relevant academic research and scientific papers
Cytotoxicity of ruthenium(II) piano-stool complexes with imidazole-based PN ligands
Huber, Wilhelm,Br?hler, Philip,W?tjen, Wim,Frank, Walter,Spingler, Bernhard,Kunz, Peter C.
, p. 187 - 194 (2012/11/06)
A series of p-cymene ruthenium(II) complexes with imidazol-2-yl phosphines as PN ligands was prepared. Depending on the number of imidazolyl substituents in the ligands Ph3-nP(im)n {1-3: n = 1-3, im = imidazol-2-yl (a), 1-methylimidazol-2-yl (b)} different coordination modes were observed: κP, κ2N,N or κ3N,N,N. The complexes were tested for their cytotoxicity in different cancer cell lines. Most of the compounds were found to be non-toxic; The compounds [(p-cymene)Ru(1a)Cl2] (4a) shows cytotoxicity towards A2780sens and Hct116 cells in the μM range but not in H4IIE cells. The cytotoxicity is decreased upon introduction of a methyl group as [(p-cymene)Ru(1b)Cl 2] (4b) shows only modest toxicities in the cell lines investigated. The κP compound [(p-cymene)Ru(2a)Cl2] (5a) shows selective toxicity in H4IIE cells after 72 h whereas the κ2N,N compound [(p-cymene)Ru(2a)Cl]OTf (5a′) showed no toxicity in the cell lines investigated which again.
Ruthenium arene derivatives with PN hemilabile ligands. P-C cleavage and phosphine to phosphinite transformation
Caballero, Agustin,Jalon, Felix A.,Manzano, Blanca R.,Espino, Gustavo,Perez-Manrique, Mercedes,Mucientes, Antonio,Poblete, Francisco J.,Maestro, Miguel
, p. 5694 - 5706 (2008/10/09)
The synthesis of ruthenium arene derivatives with hemilabile ligands was investigated. An unexpected reactivity of the ligand was observed during the course of the synthesis which was transformed by the reaction with methanol into diarylphosphinite. The transformation of [RuCl2(arene)(κ] 1-PN)] type neutral derivatives in to the cationic species [RuCl(arene)κ2-PN)]X was achieved. The protonation of the neutral derivatives with HBF4 resulted in the formation of [RuCl 2(arene)(κ1-PNH)]BF4 which exhibited a hydrogen bond.
