808172-36-3

Upstream product

• 808172-29-4 7-chloro-2-oxo-3-(3,4,5-trimethyl-phenyl)-4-(2-trimethylsilanyl-ethoxy)-1,2-dihydro-quinoline-6-carboxylic acid methyl ester 
• 335293-17-9 6-carbomethoxy-7-chloro-4-hydroxy-3-(3,4,5-trimethylphenyl)-1H-quinolin-2-one 
• 2916-68-9 2-(Trimethylsilyl)ethanol 
• 808172-32-9 7-chloro-2-oxo-3-(3,4,5-trimethyl-phenyl)-4-(2-trimethylsilanyl-ethoxy)-1,2-dihydro-quinoline-6-carboxylic acid 

Downstream Products

• 362604-28-2 7-chloro-4-hydroxy-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide 

Relevant academic research and scientific papers

Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists

Potent neutral replacements of the basic amine at the 4-position of quinolone non-peptide GnRH antagonists are reported. A series of neutral, nonbasic quinolone GnRH antagonists were prepared via Mitsunobu alkylation of protected and unprotected 4-hydroxy quinolone intermediates. The synthetic route was improved by utilization of unique reactivity and convergency afforded by the use of mono and bis-trimethylsilylethyl protected quinolones. Potent neutral GnRH antagonists were identified, including ether and lactam derivatives, that show similar in vitro binding affinity and functional activity as compared to the earlier basic 4-aminoalkyl quinolone series of nonpeptide GnRH antagonists.