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Usage

Uses

Used in Pharmaceutical Industry:
1-Benzyl-1H-1,2,3-triazole-4-carboxamide is used as an active pharmaceutical ingredient for the development of antiepileptic drugs. It functions by decreasing the firing of neurons at sodium channels, which helps in reducing seizure activity. As an anticonvulsant, it plays a crucial role in managing epilepsy and other seizure disorders.
Used in Chemical Synthesis:
1-Benzyl-1H-1,2,3-triazole-4-carboxamide can be used as a key intermediate in the synthesis of various chemical compounds. Its unique structure allows it to act as a building block for the development of new molecules with potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science.
Used in Research and Development:
1-benzyl-1H-1,2,3-triazole-4-carboxamide is also utilized in research and development settings to study the properties and potential applications of triazole-based compounds. Researchers can use 1-benzyl-1H-1,2,3-triazole-4-carboxamide to investigate its interactions with biological systems, its potential as a therapeutic agent, and its role in various chemical reactions.

Upstream product

• 7341-96-0 2-propynamide 
• 622-79-7 benzyl azide 
• 79-06-1 2-propenamide 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin

There is an urgent need for the development of efficient methodologies that accelerate drug discovery. We demonstrate that the strategic combination of fragment linking/optimization and protein-templated click chemistry is an efficient and powerful method that accelerates the hit-identification process for the aspartic protease endothiapepsin. The best binder, which inhibits endothiapepsin with an IC50value of 43 μm, represents the first example of triazole-based inhibitors of endothiapepsin. Our strategy could find application on a whole range of drug targets.

PROCESS FOR PREPARATION OF 1,2,3-TRIAZOLE-4 CARBOXAMIDES

The invention relates to the preparation of 1,2,3-triazole-4-carboxamide of general Formula I: wherein R1 and R2 may be the same or different and are selected from H, F, Cl, Br, I, OR, C(O)R, NH2, NHR or NR2. R can be a linear or branched alkyl group, for example a C1-C4 alkyl group. In exemplary embodiments, R1 and R2 are independently selected from H, F, Cl, Br, and I. The compound of Formula I can be Rufinamide.

Copper(I)-catalyzed aerobic oxidative azide-alkene cyclo-addition: An efficient synthesis of substituted 1,2,3-triazoles

A novel, copper(I)-promoted azide-alkene aerobic oxidative cycloaddition protocol was devel-oped for the regioselective synthesis of 1,4-disubsti-tuted/ 1,4,5-trisubstituted 1,2,3-triazoles by using azides and electron-deficient olefins under an oxygen atmosphere.

An abnormal N-heterocyclic carbene-copper(I) complex in click chemistry

Herein we report the synthesis of a copper(I) chloro complex using an abnormal N-heterocyclic carbene (aNHC) salt, 1,3-bis(2,6-diisopropylphenyl)-2,4- diphenylimidazolium. The Cu(aNHC) complex efficiently catalyzed Huisgen 1,3-dipolar cycloaddition reacti