80822-62-4Relevant articles and documents
Diastereoselective pictet-spengler reactions of a tethered 2-aminoimidazole
Shengule, Sudhir R.,Karuso, Peter
, p. 184 - 191 (2014/03/21)
The diastereoselective Pictet-Spengler reaction of aminopropyl-2- aminoimidazole with enantiopure aldehydes has been investigated. With amino acid-derived aldehydes, anti stereochemistry is favoured, with a diastereoselectivity up to 92% achievable. The absolute stereochemistry of the products was determined through synthesis of a rigid derivative and from NMR data in combination with molecular modelling. The diastereoselectivity was shown to be dependent on the steric bulk of the amino acid side chain and independent of the nitrogen protecting group. Lewis acids catalysed the reaction but did not affect the diastereoselectivity.
INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE DERIVATIVES
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Page/Page column 40, (2008/12/07)
Disclosure is provided for imidazole derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.