80827-26-5

Basic information

• Product Name: 1,3-Diphenyl-7,8-dimethylpyrido<1,2-a>benzimidazole
• Synonyms: 1,3-Diphenyl-7,8-dimethylpyrido<1,2-a>benzimidazole
• CAS NO: 80827-26-5
• Molecular Weight: 348.447
• Mol File: 80827-26-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,3-Diphenyl-7,8-dimethylpyrido<1,2-a>benzimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Diphenyl-7,8-dimethylpyrido<1,2-a>benzimidazole(80827-26-5)
• EPA Substance Registry System: 1,3-Diphenyl-7,8-dimethylpyrido<1,2-a>benzimidazole(80827-26-5)

Safety Data

• Hazardous Substances Data: 80827-26-5(Hazardous Substances Data)

Upstream product

• 3363-56-2 2,5,6-trimethylbenzimidazole 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 582-60-5 5,6-dimethyl-1H-benzo[d]imida-zole 
• 78288-57-0 1-Amino-5,6-dimethylbenzimidazole 
• 98-86-2 acetophenone 

Relevant articles and documents

Transition-metal-free C-N and C-C formation: Synthesis of benzo[4,5]imidazo[1,2-: A] pyridines and 2-pyridones from ynones

Herein, a transition metal-free and efficient cascade reaction of ynones with 2-methylbenzimidazoles under mild conditions has been revealed. This cascade reaction involved a Michael addition/intramolecular cycloaddition/dehydration and provided the desired benzo[4,5]imidazo[1,2-a]pyridines in moderate to good yield. Furthermore, three benzo[4,5]imidazo[1,2-a]pyridines (3d, 3i, and 3q) exhibited good activities against Hep-G2 (human liver cancer), T-24 (human bladder cancer cell), and SK-OV-3 (human ovarian cancer) cell lines with IC50 values in the range of 8.05-10.67 μmol L-1. To investigate the mechanism of the effective inhibition of cell growth, further studies, including cell cycle analysis, apoptosis ratio detection, measurement of Ca2+ generation, ROS, mitochondrial membrane potential assay, and caspase-3/9 activation, were carried out on compound 3i.