80832-58-2

Upstream product

• 2174-64-3 5-methoxyresorcinol 
• 557-21-1 dicyanozinc 
• 7647-01-0 hydrogenchloride 
• 60-29-7 diethyl ether 
• 74-90-8 hydrogen cyanide 
• 830-79-5 2,4,6-trimethoxybenzaldehyde 
• 32292-78-7 2-formyl-3,5-dihydroxyphenyl benzoate 
• 412036-33-0 2,6-dihydroxy-4-methoxy-3-trichloroacetyl-benzaldehyde 
• 161773-53-1 2-benzoyloxy-6-hydroxy-4-methoxybenzaldehyde 
• 412035-75-7 3-formyl-2,4-dihydroxy-6-methoxy-benzoic acid 

Downstream Products

• 161773-53-1 2-benzoyloxy-6-hydroxy-4-methoxybenzaldehyde 
• 909094-16-2 2-((R)-6,7-Dimethoxy-4-oxo-chroman-3-yloxy)-6-hydroxy-4-methoxy-benzaldehyde 

Relevant academic research and scientific papers

4'-Methyl derivatives of 5-MOP and 5-MOA: Synthesis, photoreactivity, and photobiological activity

The synthesis and photobiological activity of four new 4'-methyl derivatives of 5-MOP (5-methoxypsoralen) and 5-MOA (5-methoxyangelicin), i.e., 4,4'-dimethyl-5-methoxypsoralen, 3,4'-dimethyl-5-methoxypsoralen, 4,4'- dimethyl-5-methoxyangelicin, and 3,4'-dimethyl-5-methoxyangelicin, are described. All these compounds photobind efficiently to DNA. The DNA- photobinding process was investigated using various nucleic acid structures such as double-helix DNA, bacterial DNA, and synthetic polydeoxyribonucleotides. Photoreaction experiments showed that, unlike 8- MOP (8-methoxypsoralen) and 5-MOP, both angular derivatives bind thymine and cytosine with the same efficiency. The principal nucleoside-psoralen monoadducts were isolated and characterized after enzymatic digestion or acid hydrolysis. Biological activity studies revealed a good correlation with the extent of covalent photoaddition. Moreover, the two angular derivatives and the 4,4'-dimethyl-5-methoxypsoralen were unable to induce skin erythema, in striking contrast with the reference drugs, 8-MOP and 5-MOP; only the 3,4'- dimethyl-5-methoxypsoralen caused erythema, although to a substantially lower extent than that induced by the two parent compounds.

A mild and chemoselective dealkylation of alkyl aryl ethers by cerium(III) chloride-NaI

The alkoxy groups present ortho to carbonyl group in alkoxybenzaldehydes are selectively deprotected in high yields leaving other alkoxy groups unaffected by cerium(III) chloride-NaI in refluxing acetonitrile under neutral reaction conditions.