80854-57-5Relevant academic research and scientific papers
Development of new scaffolds as reversible tissue transglutaminase inhibitors, with improved potency or resistance to glutathione addition
Apperley, Kim Y. P.,Roy, Isabelle,Saucier, Vincent,Brunet-Filion, Nicholas,Piscopo, Sara-Pier,Pardin, Christophe,De Francesco, élise,Hao, Catherine,Keillor, Jeffrey W.
supporting information, p. 338 - 345 (2017/03/08)
Previous studies within our group have yielded a class of cinnamoyl-based competitive reversible inhibitors for tissue transglutaminase (TG2), with Ki values as low as 1.0 μM (compound CP4d). However, due to the electrophilic nature of their al
N-Heterocyclic Carbene-Catalyzed Activation of Esters of N-Hydroxyphthalimide: A Highly Enantioselective Route to Chiral Dihydropyridinones Bearing an All Carbon Quaternary Stereogenic Center
Zhang, Zhiming,Zeng, Xiaofei,Xie, Danbo,Chen, Dongdong,Ding, Liyuan,Wang, Anna,Yang, Limin,Zhong, Guofu
supporting information, p. 5052 - 5055 (2015/11/03)
An N-heterocyclic carbene-catalyzed highly enantioselective [3 + 3] annulation reaction of N-hydroxyphthalimide (NHPI) 3,3-disubstituted acrylates and N-Ts ketimines was developed. In most cases, the desired chiral dihydropyridinone products bearing an all carbon quaternary stereogenic center could be obtained in good yields with excellent enantioselectivities (>99% ee's), which demonstrated the NHPI acrylates as a kind of excellent substrate in NHC-catalysis.
PPAR AGONIST COMPOUNDS, PREPARATION AND USES
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Page/Page column 21, (2011/08/22)
The present invention relates to novel PPAR agonist compounds as well as pharmaceutical compositions containing them. The compounds according to the invention are of quite particular therapeutic interest, notably for treating diabetes and/or dyslipidemias, as well as for preventing cardiovascular pathologies.
Catalytic ketone olefination with methyltrioxorhenium
Pedro, Filipe M.,Hirner, Sebastian,Kühn, Fritz E.
, p. 7777 - 7779 (2007/10/03)
Methyltrioxorhenium (MTO) catalyses the olefination of ketones with ethyl diazoacetate in the presence of triphenylphosphane. Unactivated ketones require the addition of 0.5 equiv of benzoic acid to achieve good yields, while trifluoromethyl ketones require no co-catalyst. The optimised system allows the olefination of aromatic, aliphatic, unsaturated, cyclic and trifluoromethyl ketones.
