80854-59-7

Usage

Uses

Used in Organic Synthesis:
(2Z)-3-(4-nitrophenyl)but-2-enoic acid is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structure allows it to be a versatile component in the synthesis of a wide range of compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (2Z)-3-(4-nitrophenyl)but-2-enoic acid is used as a key component in the development of new drugs. Its molecular structure contributes to the formation of active pharmaceutical ingredients, which can be used to treat a variety of medical conditions.
Used in Agrochemical Industry:
(2Z)-3-(4-nitrophenyl)but-2-enoic acid is also utilized in the agrochemical industry, where it serves as a component in the formulation of various agrochemical products. Its presence in these products can help improve their effectiveness in agricultural applications, such as pest control and crop protection.

Upstream product

• 80854-57-5 3-(4-nitro-phenyl)-crotonic acid ethyl ester 
• 91671-23-7 ethyl 2-hydroxy-2-(4-nitrophenyl)butanoate 
• 100-19-6 (4-nitrophenyl)ethanone 
• 87931-46-2 3-p-nitrophenylbut-3-enoic acid 
• 704-79-0 3-phenylbut-2-enoic acid 

Downstream Products

• 21316-15-4 p-Nitro-β-methyl-zimtsaeure-p-fluorsulfonyl-anilid 
• 62-23-7 4-nitro-benzoic acid 
• 1559077-98-3 (E)-1-nitro-4-(4,4,4-trifluorobut-2-en-2-yl)benzene 
• 80854-62-2 3-(4-nitrophenyl)but-2-enoyl chloride 

Relevant academic research and scientific papers

Development of new scaffolds as reversible tissue transglutaminase inhibitors, with improved potency or resistance to glutathione addition

Previous studies within our group have yielded a class of cinnamoyl-based competitive reversible inhibitors for tissue transglutaminase (TG2), with Ki values as low as 1.0 μM (compound CP4d). However, due to the electrophilic nature of their al

N-Heterocyclic Carbene-Catalyzed Activation of Esters of N-Hydroxyphthalimide: A Highly Enantioselective Route to Chiral Dihydropyridinones Bearing an All Carbon Quaternary Stereogenic Center

An N-heterocyclic carbene-catalyzed highly enantioselective [3 + 3] annulation reaction of N-hydroxyphthalimide (NHPI) 3,3-disubstituted acrylates and N-Ts ketimines was developed. In most cases, the desired chiral dihydropyridinone products bearing an all carbon quaternary stereogenic center could be obtained in good yields with excellent enantioselectivities (>99% ee's), which demonstrated the NHPI acrylates as a kind of excellent substrate in NHC-catalysis.

Studies in Decarboxylation. Part 16. Steric Inhibition of Resonance in a 1,5-Sigmatropic Reaction

The rates of gas-phase decarboxylation of some 3-phenyl-substituted but-3-enoic acids are best rationalized in terms of steric inhibition of resonance in the more sterically crowded members.