808733-71-3Relevant academic research and scientific papers
Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: Protein structure-guided design and SAR
Richardson, Christine M.,Williamson, Douglas S.,Parratt, Martin J.,Borgognoni, Jenifer,Cansfield, Andrew D.,Dokurno, Pawel,Francis, Geraint L.,Howes, Rob,Moore, Jonathan D.,Murray, James B.,Robertson, Alan,Surgenor, Allan E.,Torrance, Christopher J.
, p. 1353 - 1357 (2007/10/03)
Crystallographic and modelling data, in conjunction with a medicinal chemistry template-hopping approach, led to the identification of a series of novel and potent inhibitors of human cyclin-dependent kinase 2 (CDK2), with selectivity over glycogen syntha
TRIAZOLO `1 , 5-A!PYRIMIDINES AND THEIR USE IN MEDICINE
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Table 1, (2008/06/13)
Compounds of formula (IA) or (AB) are kinase inhibitors, especially of CDK2, and/or PDK1 and/or CHK 1: wherein Ring A is an optionally substituted aryl, heteroaryl, carbocyclic or heterocyclic radical, Alk represents an optionally substituted clivaient C
