808734-39-6Relevant articles and documents
Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: Protein structure-guided design and SAR
Richardson, Christine M.,Williamson, Douglas S.,Parratt, Martin J.,Borgognoni, Jenifer,Cansfield, Andrew D.,Dokurno, Pawel,Francis, Geraint L.,Howes, Rob,Moore, Jonathan D.,Murray, James B.,Robertson, Alan,Surgenor, Allan E.,Torrance, Christopher J.
, p. 1353 - 1357 (2006)
Crystallographic and modelling data, in conjunction with a medicinal chemistry template-hopping approach, led to the identification of a series of novel and potent inhibitors of human cyclin-dependent kinase 2 (CDK2), with selectivity over glycogen syntha