808740-52-5

Usage

Uses

Used in Pharmaceutical Industry:
3-(2-Fluoro-phenyl)-isoxazole-5-carbaldehyde is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity allow for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
3-(2-Fluoro-phenyl)-isoxazole-5-carbaldehyde is utilized as a building block in the preparation of agrochemicals, such as pesticides and herbicides. Its chemical properties contribute to the creation of effective compounds for agricultural use.
Used in Organic Synthesis:
3-(2-Fluoro-phenyl)-isoxazole-5-carbaldehyde is employed as a versatile reactant in various organic synthesis processes. Its high reactivity enables the formation of diverse chemical products, expanding the scope of chemical research and development.
Used in Drug Discovery and Development:
Due to its unique structure and properties, 3-(2-Fluoro-phenyl)-isoxazole-5-carbaldehyde serves as a potential candidate for drug discovery and development. It can be further modified and optimized to create novel compounds with potential therapeutic effects in various medical fields.

InChI:InChI=1/C10H6FNO2/c11-9-4-2-1-3-8(9)10-5-7(6-13)14-12-10/h1-6H

Upstream product

• 446-52-6 2-Fluorobenzaldehyde 
• 24652-66-2 2-fluorobenzaldehyde oxime 
• 953046-62-3 [3-(2-fluorophenyl)isoxazol-5-yl]methanol 

Downstream Products

• 953046-63-4 1-(3-(2-fluorophenyl)isoxazol-5-yl)methylpiperazine 
• 1337539-75-9 C₂₆H₃₀ClFN₄O 
• 1337539-74-8 C₂₇H₃₃FN₄O 
• 1337539-73-7 C₃₃H₃₅F₃N₄O 
• 1337539-72-6 C₂₆H₃₀F₂N₄O 
• 1337539-68-0 C₂₇H₃₃FN₄O₂ 
• 1337539-65-7 C₂₆H₃₀ClFN₄O 
• 1337539-51-1 C₂₆H₃₁FN₄O 
• 1337539-61-3 C₂₆H₃₀ClFN₄O 
• 1337539-57-7 C₂₆H₃₀F₂N₄O 

Relevant academic research and scientific papers

A rapid and efficient solvent-free microwave-assisted synthesis of pyrazolone derivatives containing substituted isoxazole ring

An efficient synthesis of 4-substituted pyrazolone derivatives was developed. 4-Substituted pyrazolone derivatives were synthesized in 78-97% yields starting from various 3-substituted isoxazole-5-carbaldehydes, ethyl acetoacetate and hydrazine under micr

An efficient solvent-free synthesis of isoxazolyl-1,4-dihydropyridines on solid support SiO2 under microwave irradiation

An efficient synthesis of 1,4-dihydropyridines was developed. 1,4-Dihydropyridines were synthesized starting from various 3-substituted isoxazolyl-5-carbaldehydes, ethyl acetoacetate, and ammonium acetate under microwave irradiation and solvent-free conditions (86–96?%), and were characterized by HRMS, FT-IR, 1H NMR, and 13C NMR spectroscopy. Solid support SiO2 was found to possess favorable catalysis and dispersancy for the condensation reaction. The merits of the method included the environmental friendly reaction conditions, simple operation, extensive substrates, good yields and reuse of the SiO2. Moreover, the crystal structure of compound diethyl 4-[3-(2-methoxyphenyl)isoxazol-5-yl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate in orthorhombic Pbca space group was presented. Graphical abstract: [Figure not available: see fulltext.]

ISOXAZOLE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS

Methods and compounds effective in ameliorating conditions characterized by unwanted calcium channel activity, particularly unwanted N-type or T-type calcium channel activity are disclosed. Specifically, a series of isoxazole containing compounds are disclosed of the general formula (1) where Z is N or CHNR3 and (Ar1)2CR4 is optionally substituted benzhydryl.

Synthesis and biological evaluation of novel T-type Ca2+ channel blockers

A small molecule library of piperazinylalkylisoxazole derivatives containing about 600 compounds was designed, synthesized and evaluated for blocking effects on T-type Ca2+ channel. Several ligands were identified to possess high inhibitory activity against the T-type Ca 2+ channel. The compound 21 with trifluoromethyl substituents at C3-position of phenyl group (R1) and C2- position of phenyl group (R2) showed the highest inhibitory activity with IC50 value of 1.02μM, which is comparable to that of mibefradil.