808771-17-7Relevant academic research and scientific papers
Synthesis of the C7-26 fragment of amphidinolides G and H
Hara, Akihiro,Morimoto, Ryo,Ishikawa, Yuichi,Nishiyama, Shigeru
, p. 4036 - 4039 (2011)
A new approach to the synthesis of the C7-26 fragment of amphidinolides G and H was developed. In the sequence, the C7-18 portion of this fragment was synthesized using an acetylide coupling protocol, while an Evans alkylation and Sharpless asymmetric dihydroxylation were employed as key steps in construction of the C19-26 subfragment. Finally, both of these units were joined by utilizing an aldol coupling reaction to produce the target C7-26 fragment in good yield.
Total synthesis of (+)-bongkrekic acid
Shindo, Mitsuru,Sugioka, Tomoyuki,Umaba, Yuko,Shishido, Kozo
, p. 8863 - 8866 (2007/10/03)
Total synthesis of bongkrekic acid, an important apoptosis inhibitor, has been accomplished. The strategy includes inexpensive starting materials, asymmetric alkylation, anionic allyl coupling and oxidative manipulations. This process would provide a sufficient amount of bongkrekic acid and its analogues.
