1315317-47-5

Upstream product

• 1033074-47-3 (S)-1-((5,5-dibromo-3-methylpent-4-enyloxy)methyl)-4-methoxybenzene 
• 1033074-22-4 (S)-1-methoxy-4-((3-methylpent-4-ynyloxy)methyl)benzene 
• 1029083-72-4 (2S,3S)-5-(4-methoxybenzyloxy)-3-methylpentane-1,2-diol 
• 322474-61-3 C₉H₁₆O₄ 
• 1312136-34-7 (R)-4-benzyl-3-(3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-propanoyl)oxazolidin-2-one 
• 1312135-98-0 (R)-4-benzyl-3-((R)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-methylpropanoyl)oxazolidin-2-one 
• 1315317-39-5 (S,E)-7-(tert-butyldiphenylsilyloxy)-3-methylhept-5-enenitrile 
• 1315317-38-4 (S,E)-7-(tert-butyldiphenylsilyloxy)-3-methylhept-5-enal 
• 1315317-40-8 (3S,8S,E)-12-(tert-butyldiphenylsiloxy)-1-(4-methoxybenzyloxy)-3,8-dimethyldodec-10-en-4-yn-6-one 
• 1315317-41-9 (7S,12S,E)-3,3-diethyl-7,12,19,19-tetramethyl-18,18-diphenyl-4,17-dioxa-3,18-disilaicos-14-en-8-yn-10-one 
• 1315317-50-0 C₃₀H₄₀O₃Si 
• 1315317-42-0 (7S,8E,12S,14E)-3,3-diethyl-7,8,12,19,19-pentamethyl-18,18-diphenyl-4,17-dioxa-3,18-disilaicosa-8,14-dien-10-one 
• 1315317-43-1 (6E,9S,12E,14S)-18,18-diethyl-2,2,9,13,14-pentamethyl-11-methylene-3,3-diphenyl-4,17-dioxa-3,18-disilaicosa-6,12-diene 
• 1315317-51-1 (3S,4E,8S,10E)-12-(tert-butyldiphenylsilyloxy)-3,4,8-trimethyl-6-methylenedodeca-4,10-dien-1-ol 

Relevant academic research and scientific papers

Total syntheses of amphidinolides B, G, and H

Not one, not two, but three: Total syntheses of amphidinolides B, G, and H, which exhibit strong, nanogram-scale cytotoxicity against various tumor cell lines, have been executed. The synthetic strategy relied on implementation of a diene construction protocol and a diastereoselective aldol process. The 26- and 27-membered macrocyclic lactone rings were efficiently constructed by using ring-closing metathesis (RCM). Copyright

Synthesis of the C7-26 fragment of amphidinolides G and H

A new approach to the synthesis of the C7-26 fragment of amphidinolides G and H was developed. In the sequence, the C7-18 portion of this fragment was synthesized using an acetylide coupling protocol, while an Evans alkylation and Sharpless asymmetric dihydroxylation were employed as key steps in construction of the C19-26 subfragment. Finally, both of these units were joined by utilizing an aldol coupling reaction to produce the target C7-26 fragment in good yield.