80882-55-9

Basic information

• Product Name: 1-(2-N,N-dimethylamino-4-pyridyl)-1-ethanone oxime O-tosylate
• CAS NO: 80882-55-9
• Molecular Weight: 333.411
• Mol File: 80882-55-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-N,N-dimethylamino-4-pyridyl)-1-ethanone oxime O-tosylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-N,N-dimethylamino-4-pyridyl)-1-ethanone oxime O-tosylate(80882-55-9)
• EPA Substance Registry System: 1-(2-N,N-dimethylamino-4-pyridyl)-1-ethanone oxime O-tosylate(80882-55-9)

Safety Data

• Hazardous Substances Data: 80882-55-9(Hazardous Substances Data)

Upstream product

• 80882-53-7 1-(2-dimethylamino-4-pyridyl)-1-ethanone 
• 80882-52-6 2-dimethylaminoisonicotinonitrile 
• 80882-54-8 1-(2-N,N-dimethylamino-4-pyridyl)-1-ethanone oxime 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

The synthesis of 2-amino-4-(4-imidazolyl)pyridines

A general synthetic scheme for the preparation of 2-amino-4-(4-imidazolyl)pyridines, potential histamine H2 antagonists, is described. The synthesis is based on the Neber rearrangement of 1-(4-pyridyl)-l-alkanone oxime O-tosylates to the appropriate α-aminoketones or α-aminoketals, which are then converted to the corresponding imidazoles. The reaction of Grignard reagents with 2-chloroisonicotinonitrile, as well as nucleophilic displacement of chloride by amines on 2-chloroisonicotinonitrile and derivatives, are discussed in relation to the preparation of the ketone intermediates.