80882-52-6

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(dimethylamino)isonicotinonitrile is utilized as a building block in the preparation of various pharmaceuticals. Its unique structure allows it to be incorporated into the synthesis of a wide array of medicinal compounds, contributing to the development of new drugs.
Used in Agrochemical Production:
In the agrochemical industry, 2-(dimethylamino)isonicotinonitrile serves as a key component in the synthesis of different agrochemicals. Its application aids in the creation of products designed to protect crops and enhance agricultural productivity.
Used as a Reagent in Heterocyclic Compound Synthesis:
2-(dimethylamino)isonicotinonitrile is employed as a reagent in the synthesis of heterocyclic compounds. Its ability to engage in various chemical reactions facilitates the formation of complex heterocyclic structures, which are important in the field of organic chemistry.
Used as a Precursor for Functionalized Molecules:
2-(dimethylamino)isonicotinonitrile also acts as a precursor for the preparation of various functionalized molecules. Its presence in the synthesis process allows for the creation of molecules with specific properties, which can be tailored for use in different applications across various industries.

Upstream product

• 33252-30-1 2-chloro-4-pyridinenitrile 
• 124-40-3 dimethyl amine 

Downstream Products

• 1260433-28-0 4-(4-amino-2-(3-chlorophenyl)-5-methyl-2H-imidazol-2-yl)-N,N-dimethylpyridin-2-amine 
• 1260432-45-8 4-(4-amino-2-(3'-methoxybiphenyl-3-yl)-5-methyl-2H-imidazol-2-yl)-N,N-dimethylpyridin-2-amine 
• 1260433-27-9 4-((3-chlorophenyl)(imino)methyl)-N,N-dimethylpyridin-2-amine 
• 1016772-06-7 2-methylaminothioisonicotinamide 
• 80882-55-9 1-(2-N,N-dimethylamino-4-pyridyl)-1-ethanone oxime O-tosylate 

Relevant academic research and scientific papers

Acridone-based inhibitors of inosine 5′-monophosphate dehydrogenase: Discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1- yl)pyridin-3-yl)propan-2-yl)-2-fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419)

Inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo synthesis of guanosine nucleotides, catalyzes the irreversible nicotinamide-adenine dinucleotide dependent oxidation of inosine-5′- monophosphate to xanthosine-5′-monophosphate. Mycophenolate Mofetil (MMF), a prodrug of mycophenolic acid, has clinical utility for the treatment of transplant rejection based on its inhibition of IMPDH. The overall clinical benefit of MMF is limited by what is generally believed to be compound-based, dose-limiting gastrointestinal (GI) toxicity that is related to its specific pharmacokinetic characteristics. Thus, development of an IMPDH inhibitor with a novel structure and a different pharmacokinetic profile may reduce the likelihood of GI toxicity and allow for increased efficacy. This article will detail the discovery and SAR leading to a novel and potent acridone-based IMPDH inhibitor 4m and its efficacy and GI tolerability when administered orally in a rat adjuvant arthritis model.

Pyrid-2-one derivatives and methods of use

Selected compounds are effective for treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving stroke, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.