80896-75-9

Usage

Uses

Used in Pharmaceutical Applications:
Trans-1-benzyl-4-p-tolylpyrrolidine-3-carboxylic acid is used as a drug candidate for the treatment of different medical conditions. Its unique structure and properties contribute to its potential therapeutic effects, making it a promising compound for further research and development in the pharmaceutical industry.
Used in Organic Synthesis:
In the field of organic synthesis, Trans-1-benzyl-4-p-tolylpyrrolidine-3-carboxylic acid is used as a building block to create more complex molecules with potential biological activities. Its versatile structure allows for the development of new compounds with improved pharmacological properties, enhancing the scope of drug discovery and innovation.
Used in Drug Discovery and Development:
Trans-1-benzyl-4-p-tolylpyrrolidine-3-carboxylic acid is utilized in drug discovery and development processes to explore its potential as a lead compound for the creation of new therapeutic agents. Its unique chemical properties and structure make it a valuable asset in the search for novel treatments for various diseases and medical conditions.

InChI:InChI=1/C19H21NO2/c1-14-7-9-16(10-8-14)17-12-20(13-18(17)19(21)22)11-15-5-3-2-4-6-15/h2-10,17-18H,11-13H2,1H3,(H,21,22)/t17-,18+/m1/s1

Upstream product

• 5720-05-8 4-methylphenylboronic acid 
• 698358-08-6 tert-butyl 1-(phenylmethyl)-2,5-dihydropyrrole-3-carboxylate 
• 104-87-0 4-methyl-benzaldehyde 
• 20511-20-0 ethyl (Z)-3-(4-methylphenyl)-2-propenoate 

Relevant academic research and scientific papers

SULFONYL PYRROLIDINES, METHOD FOR PRODUCING THE SAME AND THEIR USE AS DRUGS

The invention relates to substituted sulfonylpyrrolidines of the formula I and to the physiologically tolerated salts thereof, as well as to their use as medicaments.

The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist

5-HT2C agonists have shown efficacy in limiting food consumption and thus may serve as an important drug class in combating obesity. We describe the design and synthesis of a novel tricyclic single-nitrogen scaffold that was used to produce 5-HT2C agonists. SAR was developed around this chemotype and compounds were identified that were potent (Ki 2 receptors. The most promising compound displayed a good pharmacokinetic profile in multiple animal species, and was efficacious in an acute feeding study in rats.

Tricyclic indeno-pyrrole derivatives as serotonin receptor modulators

The present invention generally relates to a series of compounds, to pharmaceutical compositions containing the compounds, and to use of the compounds and compositions as therapeutic agents. More specifically, compounds of the present invention are tricyclic indeno-pyrrole compounds. These compounds are serotonin receptor (5-HT) ligands and are useful for treating diseases, disorders, and conditions wherein modulation of the activity of serotonin receptors (5-HT) is desired (e.g. anxiety, depression and obesity).

A rapid catalytic asymmetric synthesis of 1,3,4-trisubstituted pyrrolidines

The asymmetric synthesis of 1,3,4-trisubstituted pyrrolidines was accomplished in two steps from readily available starting materials. A 1,3-dipolar cycloaddition of an azomethine ylide to a propiolate ester followed by a Rh-catalyzed asymmetric 1,4-arylation of the resulting pyrroline with an arylboronic acid provided the desired 1,3,4-trisubstituted pyrrolidine products in good to excellent enantioselectivities.

Synthesis of Phenyl- and Benzyl-Substituted Pyrrolidines and of a Piperidine by Intramolecular C-Alkylation. Synthons for Tricyclic Skeletons

The construction of new or novelly functionalized annulated and bridged tricyclic compounds by two consecutive C,C-bond formations (a and b in 1a, Scheme 1) is described.In a first step, Chloroalkyl-substituted aminonitriles yielded pyrrolidines 8, 15a, 1