80914-32-5Relevant academic research and scientific papers
Dynamic kinetic resolution of β-amino esters by a heterogeneous system of a palladium nanocatalyst and candida antarctica lipase A
Engstroem, Karin,Shakeri, Mozaffar,Baeckvall, Jan-E.
, p. 1827 - 1830 (2011)
A dynamic kinetic resolution (DKR) of β-amino esters have been developed by the use of a heterogeneous racemization catalyst and an immobilized enzyme that accepts aromatic, heteroaromatic and aliphatic substrates. The reaction conditions were optimized to yield an efficient catalytic system without by-product formation. The products are obtained in 96-99 % ee and high yields. Copyright
Thiocarbonyl Olefination, IV. - Preparation of β-Amino Acids from N-(Acetyl)thioamides; Total Synthesis of Iturinic Acid
Slopianka, Marion,Gossauer, Albert
, p. 2258 - 2265 (2007/10/02)
A new method for the synthesis of β-amino acids is described whose key step consists in the regioselective thiocarbonyl olefination of N-(acetyl)thioamides with methyl (triphenylphosphoranylidene)acetate.By this procedure, a straightforward synthesis of iturinic acid has been carried out for the first time.
