80919-05-7

Upstream product

• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 1499-21-4 Diphenylphosphinic chloride 

Downstream Products

• 57294-39-0 Z-Val-Gly-OBzl 
• 1707-03-5 diphenyl-phosphinic acid 
• 73144-19-1 N_α-benzyloxycarbonyl-leucylvalylalanine phenyl ester 
• 96886-59-8 valylalanine phenyl ester hydrobromide 
• 5849-36-5 diphenylphosphinic anhydride 
• 10084-80-7 N^α-benzyloxycarbonyl-L-valine anhydride 
• 73144-18-0 N_α-benzyloxycarbonylvalylalanine phenyl ester 
• 35761-09-2 Cbz-L-val-L-val-Cbz 

Relevant academic research and scientific papers

A KINETIC STUDY OF PHOSPHINIC CARBOXYLIC MIXED ANHYDRIDES

Using 32.4 MHz (31)P n.m.r. spectroscopy, disproportionation of a series of phosphinic carboxylic mixed anhydrides derived from protected α-amino acids has been studied both as a function of the substituents at phosphorus and structure of the α-amino acid being activated.It was found that the rates of disproportionation were insignificant from a preparative aspect compared with aminolysis at 0 deg C.

Application of Diphenylphosphinic Carboxylic Mixed Anhydrides to Peptide Synthesis.

Diphenylphosphinic carboxylic mixed anhydrides formed in situ from Nα-protected amino acids and diphenylphosphinic chloride have been critically evaluated in peptide synthesis.Wherever possible, 32.4 MHz 31P n.m.r. spectroscopy has been employed to follow the rates of both mixed anhydride formation and aminolysis.