35761-09-2Relevant academic research and scientific papers
Peptide Mechanosynthesis by Direct Coupling of N-Protected α-Amino Acids with Amino Esters
Porte, Vincent,Thioloy, Marion,Pigoux, Titouan,Métro, Thomas-Xavier,Martinez, Jean,Lamaty, Frédéric
supporting information, p. 3505 - 3508 (2016/07/28)
In view of developing alternatives to classical peptide synthesis strategies that suffer from low efficacy and negative environmental impact, the reactivity of N-protected α-amino acids, amino esters, and N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide was
The small peptide-catalyzed direct asymmetric aldol reaction in water
Dziedzic, Pawel,Zou, Weibiao,Hafren, Jonas,Cordova, Armando
, p. 38 - 40 (2007/10/03)
The asymmetric aldol reaction is a powerful method for forming carbon-carbon bonds. Small peptides with a primary amine as the catalytic residue catalyze asymmetric aqueous aldol reactions between unmodified ketones and aldehydes to furnish the corresponding aldol products with high ees. The high momodularity of the small peptides should enable the construction of several novel catalysts by combinatorial techniques for the aqueous asymmetric aldol reaction. The remarkably high difference in stereoselectivity between the peptide bond-formation was an important step towards the evaluation of asymmetric catalysis and homochilarity.
Small peptides as modular catalysts for the direct asymmetric aldol reaction: Ancient peptides with aldolase enzyme activity
Zou, Weibiao,Ibrahem, Ismail,Dziedzic, Pawel,Sunden, Henrik,Cordova, Armando
, p. 4946 - 4948 (2007/10/03)
Simple peptides and their analogues having a primary amino group as the catalytic residue mediate the direct asymmetric intermolecular aldol reaction with high stereoselectivity and furnish the corresponding aldol products with up to 99% ee; this intrinsic ability of highly modular peptides may explain the initial molecular evolution of aldolase enzymes. The Royal Society of Chemistry 2005.
N,N'-Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic Azide: A Useful Coupling Agent in Peptide Synthesis
Katti, S. B.,Misra, P. K.,Haq, W.,Mathur, K. B.
, p. 3 - 4 (2007/10/02)
N,N'-Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic azide (BOPA), has been developed as an efficient coupling reagent in peptide synthesis.Coupling reaction proceeds smoothly with no detectable racemization.
A KINETIC STUDY OF PHOSPHINIC CARBOXYLIC MIXED ANHYDRIDES
Ramage, Robert,Atrash, Butrus,Hopton, David,Parrott, Maxwell J.
, p. 1617 - 1622 (2007/10/02)
Using 32.4 MHz (31)P n.m.r. spectroscopy, disproportionation of a series of phosphinic carboxylic mixed anhydrides derived from protected α-amino acids has been studied both as a function of the substituents at phosphorus and structure of the α-amino acid being activated.It was found that the rates of disproportionation were insignificant from a preparative aspect compared with aminolysis at 0 deg C.
