80967-34-6

Usage

Class

Phenethylamine

Usage

Recreational drug formulations, potential treatment for depression and mood disorders, building block for pharmaceutical synthesis

Psychoactive Effects

Yes

Receptors

Potent agonist at serotonin 5-HT2A and 5-HT2C receptors

Recreational Drug Concerns

Potential for abuse and adverse health effects

Applications

Organic chemistry, synthesis of pharmaceuticals and complex molecules

Upstream product

• 75-15-0 carbon disulfide 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 1403495-72-6 6-(4-fluorophenyl)-N-(2-hydroxyethyl)-4-(methylthio)-2-oxo-2H-pyran-3-carboxamide 
• 1403495-86-2 6-(4-fluorophenyl)-N-(2-hydroxyethyl)-2-oxo-4-(piperidin-1-yl)-2H-pyran-3-carboxamide 
• 1616775-93-9 4-amino-3-(4-fluorobenzoyl)-2-(methylsulfanyl)naphthalene-1-carbonitrile 
• 1616775-95-1 4-amino-2-methylsulfanyl-3-(4-methylsulfanylbenzoyl)naphthalene-1-carbonitrile 
• 1422525-24-3 C₁₉H₁₇FN₂O₂S₂ 
• 1422525-23-2 C₁₇H₁₃FN₂OS₂ 
• 251940-05-3 1-(4-fluoro-phenyl)-2-(tetrahydro-pyrimidin-2-ylidene)-ethanone 

Relevant academic research and scientific papers

Transition metal free synthesis of multifunctional thiomethylated-benzenes from aryl/heteroaryl/cyclopropyl methyl ketones

A base-promoted strategic synthesis of various functionalized thiomethylated-benzenes has been established from aryl/heteroaryl/cyclopropyl methyl ketone. We can directly access the thiomethylated-benzene nucleus embedded with diverse functional group by

Synthesis of Partially Reduced Imidazo[1,2- a ]pyridines through an Unprecedented Base-Mediated (4+2) Cyclization

A water-mediated regioselective synthesis of 6,7-diaryl-5-oxo-2,3,5,6-tetrahydroimidazo[1,2-a]pyridine-6-carbonitriles was performed by the reaction of 2-[1-cyano-2,2-bis(methylsulfanyl)vinyl]benzonitrile with 1-aryl-2-(imidazolidin-2-ylidene)ethanones un

Synthesis and molecular docking studies of novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives: Using ring-opening reactions of cyclic ketene-N,O-acetal

A series of six novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives have been synthesized starting from commercially available substituted acetophenones via Oxoketene Dithioacetals with high yields. Ketene dithioacetal store act with 2-amino

Synthesis and anti-HCV determinant motif identification in pyranone carboxamide scaffold

Hepatitis C Virus exhibits high genetic diversity. The current treatment for genotype-1 with ～80% sustained virologic responses is a combination of pegylated interferon, ribavirin and boceprevir/telaprevir/simeprevir which is associated with several side

Synthesis and anti-HCV activity of 4-hydroxyamino α-pyranone carboxamide analogues

High genetic variability in hepatitis C virus (HCV), emergence of drug resistant viruses and side effects demand the requirement for development of new scaffolds to show an alternate mechanism. Herein, we report discovery of new scaffold I based on 4-hydr

Base mediated synthesis of α-aminated aroyl/acetylnaphthalenes through [4+2] annulations

We have developed a base promoted simple, efficient and alternative approach for the synthesis of 4-amino-3-aroyl//heteroaroyl/acetyl-2-methylsulfanyl-naphthalene-1-carbonitriles by reaction of easily accessible 3,3-bis(methylthio)-1-aryl/heteroaryl/acety

A convenient base-mediated synthesis of 3-aryol-4-methyl (or benzyl)-2-methylthio furans from α-oxo ketene dithioacetals and propargyl alcohols via domino coupling/annulations

A convenient base-mediated strategy to synthesize 3-aryol-4-methyl (or benzyl)-2-methylthio furans 2 (trisubstituted furans) has been developed through the domino coupling/annulations between available α-oxo ketene dithioacetals 1 and propargyl alcohols.

Three-component synthesis of indanone-fused spirooxindole derivatives

A simple, straightforward and versatile multicomponent protocol for the synthesis of indanone-fused spirooxindole derivatives has been developed. The strategy involves the one-pot three-component reaction of heterocyclic ketene aminals, 1H-indene-1,3(2H)-

Structure based molecular design, synthesis and biological evaluation of α-pyrone analogs as anti-HSV agent

Several options for treating Herpes Simplex Virus type 1 and type 2 are available. However, non-specific inhibition and drug resistance warrants the discovery of new anti-herpetic compounds with better therapeutic profile or different mode of action. The

Regioselective synthesis of functionalized 3-(methylthio)phenols by the first formal [3+3] cyclocondensations of 1,3-bis(trimethylsilyloxy)-1,3- butadienes with 1,1-bis(methylthio)-1-en-3-ones

The [3+3] cyclocondensation of 1,3-bis(silyl enol ethers) with 1,1-bis(methylthio)-1-en-3-ones results in the regioselective formation of 3-(methylthio)phenols. The products represent useful synthetic building blocks, which are not readily available by ot