80986-17-0

Usage

Uses

Used in Pharmaceutical Industry:
(R)-(-)-4-METHYLGLUTARIC ACID 1-MONOMETHYL ESTER is used as an intermediate for the manufacturing of pharmaceuticals, contributing to the development of new drugs and pharmaceuticals.
Used in Fragrance Industry:
(R)-(-)-4-METHYLGLUTARIC ACID 1-MONOMETHYL ESTER is used as a building block in the production of various esters, which are widely utilized in the flavor and fragrance industry due to their fruity, ester-like odor.
Used in Fine Chemicals Industry:
(R)-(-)-4-METHYLGLUTARIC ACID 1-MONOMETHYL ESTER is also used as an intermediate in the manufacturing of other fine chemicals, showcasing its versatility in different chemical applications.

Upstream product

• 14035-94-0 dimethyl 2-methylglutarate 
• 93633-32-0 5-methoxy-2-methylene-5-oxopentanoic acid 

Downstream Products

• 960062-27-5 C₅₃H₅₃N₁₃O₁₀S₆ 

Relevant academic research and scientific papers

Impact on hydrogenation catalytic cycle of the R groups Cyclic feature in "r-SMS-Phos"

A series of R-SMS-Phos ligands was evaluated in the Rh(I)-catalyzed hydrogenation of a set of olefins showing a marked influence of the cyclic nature and structure of the R groups. Overall, cPen- and Cy-SMS-Phos performed efficiently, while Ph- and Bn-SMS-Phos exhibited slower kinetics and furnished lower ees also compared with C6F5CH2-SMS-Phos. The Rh(I)-(Cy-SMS-Phos) catalyst was screened under mild conditions displaying excellent enantioselectivities and high TOFs. Cases of catalysis under catalyst or substrate control were identified.

Esterase catalyzed regio-and enantio-selective hydrolysis of substituted carboxylates

Optically active α-substituted carboxylic acid derivatives were obtained with regio-and enantio-selective hydrolysis catalyzed by esterase from Pseudomonas putida MR-2068. Substrate specificities were summarized in empirical rule to predict the enantiopreferences of the esterase. High regio-selectivities were also discussed with binding models.

Enzymatic Preparation of Alkanedicarboxylic Acid Monoesters

Hydrolysis of alkanedicarboxylic acid dimethyl esters using esterase from Pseudomonas putida MR-2068 gave exclusively pure monoesters.Hydrolytic activities were dependent on the carbon chain length of the substrates.This esterase also catalyzed enantio- and regio-selective hydrolysis of α-methylalkanedicarboxylic acid dimethyl esters.