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Usage

Uses

Used in Pharmaceutical Industry:
1-[3-(TRIFLUOROMETHYL)PHENYL]BUT-1-EN-3-ONE is used as a building block for the synthesis of new drugs. Its unique structure and reactivity contribute to the development of pharmaceutical compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-[3-(TRIFLUOROMETHYL)PHENYL]BUT-1-EN-3-ONE serves as a key intermediate for the production of agricultural products. Its properties allow for the creation of compounds that can be utilized in crop protection and other agrochemical applications.
Used in Fine Chemicals Production:
1-[3-(TRIFLUOROMETHYL)PHENYL]BUT-1-EN-3-ONE is used as an important intermediate in the production of fine chemicals. Its structure and properties make it a valuable component in the synthesis of specialty chemicals used across various industries.
Used in Materials Science:
1-[3-(TRIFLUOROMETHYL)PHENYL]BUT-1-EN-3-ONE also finds application in materials science, where it is utilized in the development of new materials with specific properties. Its role as an intermediate aids in the creation of innovative materials for diverse applications.

InChI:InChI=1/C11H9F3O/c1-8(15)5-6-9-3-2-4-10(7-9)11(12,13)14/h2-7H,1H3/b6-5+

Upstream product

• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 67-64-1 acetone 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 

Downstream Products

• 52451-42-0 4-Ethoxy-2-oxo-6-(3-trifluoromethyl-phenyl)-cyclohex-3-enecarboxylic acid ethyl ester 
• 205129-31-3 C₂₀H₁₅F₃O₄ 
• 1442690-00-7 1-(2-(4-fluorobenzoyl)-3-(3-(trifluoromethyl)phenyl)cyclopropyl)ethanone 

Relevant academic research and scientific papers

Discovery of novel 5-methyl-1H-pyrazole derivatives as potential antiprostate cancer agents: Design, synthesis, molecular modeling, and biological evaluation

Androgen receptor (AR) signaling functions as a core driving force for the progression of prostate cancer (PCa), and AR has been proved to be an effective therapeutic target even for castration-resistant prostate cancer (CRPC). Herein, structural modification via a fragments splicing strategy was performed based on two lead compounds T3 and 10e, leading to the discovery of a series of 5-methyl-1H-pyrazole derivatives. AR reporter gene assay revealed compounds A13 and A14 as potent AR antagonists. Some of the compounds in this series inhibited growth of PCa LNCaP cells more efficiently than enzalutamide. A13 and A14 also showed improved metabolic stability compared with 10e in human liver microsomes.

Rh(III)-Catalyzed Enaminone-Directed Alkenyl C-H Activation for the Synthesis of Salicylaldehydes

A Rh(III)-catalyzed enaminone-directed alkenyl C-H coupling with alkynes for the synthesis of salicylaldehyde derivatives is reported. This represents a unique example of benzene ring framework formation through a transition-metal-catalyzed, directed C-H activation strategy. The two incorporated reactive functionalities, aldehyde and hydroxy groups, provide convenient synthetic handles for further structural elaboration.

Diastereoselective synthesis of β-amino ketone and acid derivatives by palladium-catalyzed conjugate addition

The first diastereoselective synthesis of β-amino ketone and β-amino acid derivatives by palladium-catalyzed conjugate addition of arylboronic acids to chiral β-enamino ketones and β-enamino esters is reported. The catalytic system employing (S)-4-(tert-butyl)oxazolidin-2-one as the chiral auxiliary in water under an air atmosphere provides β-amino ketone and β-amino acid derivatives in high yields with excellent diastereoselectivity.

Synthesis and Antimalarial Properties of 1-Imino Derivatives of 7-Chloro-3-substituted-3,4-dihydro-1,9(2H,10H)-acridinediones and Related Structures

To improve upon the activity and properties of the 3-aryl-7-chloro-3,4-dihydro-1,9(2H,10H)-acridinediones, a variety of 1-imino derivatives (3) were prepared and shown to be highly active antimalarial agents in both rodents and primates.Among structural modifications prepared, including N10-alkyl and C2-substituted analogs, removal of the C9 oxygen, and introduction of an imino side chain at C9, the imines of the N10-H acridinediones were the most active compounds obtained.The imino derivative of7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1,9(2H,10H)-acridinedione (9aa) proved to be highly active in advanced studies in primates.