80993-29-9Relevant academic research and scientific papers
Unexpected non-stability of aminophosphonates: Limitation of their synthesis using diphenylmethylamine procedure
Zon,Miziak,Rychlewski,Gancarz
, p. 2023 - 2030 (2008/09/18)
New diethyl 1-diphenylmethylaminoalkylphosphonates from aldehydes, ketones, diphenylmethylamine and diethyl phosphite were obtained. Their stability in acidic media as determined by 31P NMR spectroscopy strongly depends on the basicity of the nitrogen atom. The bulky N-substituent can drastically decrease the stability of the ester during acidic hydrolysis leading to decomposition products in the retro Kabachnik-Fields like reaction.
Synthesis of 1-Aminoalkane Phosphonic Acids via Benzhydrylic Schiff Bases
Issleib, Kurt,Doepfer, Klaus-Peter,Balszuweit, Arno
, p. 1392 - 1394 (2007/10/02)
A simple synthesis of 1-aminoalkanephosphonic acids is described.The addition of diethylphosphite to alkylidene- and arylidenebenzhydrylamines yields the N-benzhydryl-1-aminoalkanephosphonic acid esters.The title compounds are formed by treatment of the N-blocked esters with hydrobromic acid.The starting amine can be recycled from the hydrylbromide. - Key words: 1-Aminoalkane Phosphonic Acids, Benzhydrylic, Schiff Bases
