81014-01-9

Upstream product

• 80999-70-8 (Z)-3-(1,3-Dimethyl-2,6-dioxo-5-p-tolylazo-1,2,3,6-tetrahydro-pyrimidin-4-ylamino)-acrylic acid ethyl ester 
• 63351-23-5 6-amino-1,3-dimethyl-5-[(4-methylphenyl)diazenyl]uracil 
• 2879-16-5 8-hydroxymethyltheophylline 

Relevant academic research and scientific papers

A Novel Synthesis of Theophylline Derivatives

Treatment of 6-amino-5-arylazo-1,3-dimethyluracils with ethyl propiolate gave the corresponding Michael-type adducts, 5-arylazo-1,3-dimethyl-6-ethoxycarbonylvinylaminouracils, which on treatment with a mixture of hydrochloric acid and acetic acid caused the acid-catalyzed rearrangement accompanied with rearrangement to give rise to the corresponding 8-anilinomethyltheophylline derivatives.In the case that the arylazo group possesses an electron-releasing substituent such as methoxy, the reaction proceeded ina different way to afford 1,2-bis(theophyllin-8-yl)ethane.The presumable reaction mechanisms for the above purine syntheses were proposed.

A NOVEL SYNTHESIS OF THEOPHYLLINE DERIVATIVES

Treatment of 6-amino-5-arylazo-1,3-dimethyluracils with ethyl propiolate gave the corresponding Micgael-adducts, 6-ethoxycarbonylvinylaminouracils, which on treatment with a mixture of hydrochloric acid and acetic acid gave rise to 8-anilinomethyltheophylline derivatives.