2879-16-5

Usage

Uses

Used in Pharmaceutical Industry:
3,7-Dihydro-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6-dione is used as a bronchodilator for the treatment of respiratory conditions such as asthma, chronic obstructive pulmonary disease (COPD), and bronchitis. It functions by relaxing the smooth muscles in the airways, improving breathing capacity.
Used in Cardiac Stimulation:
In the pharmaceutical industry, 3,7-Dihydro-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6-dione is also utilized for its mild cardiac stimulation effects, which can be beneficial in certain cardiovascular conditions.
Used in Diuretic Applications:
3,7-Dihydro-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6-dione serves as a mild diuretic, promoting the excretion of excess water and salts from the body, which can be useful in managing fluid retention and certain kidney-related conditions.
Used in Anti-inflammatory and Immunomodulatory Research:
Although its use in this area is not as established, 3,7-Dihydro-8-(hydroxymethyl)-1,3-dimethyl-1H-purine-2,6-dione is being studied for potential anti-inflammatory and immunomodulatory properties, which could lead to new therapeutic applications in various inflammatory and immune-related disorders.

InChI:InChI=1/C8H10N4O3/c1-11-6-5(9-4(3-13)10-6)7(14)12(2)8(11)15/h13H,3H2,1-2H3,(H,9,10)

Upstream product

• 79-14-1 glycolic Acid 
• 5440-00-6 4,5-Diamino-1,3-dimethyluracil 
• 67-56-1 methanol 
• 58-55-9 theophylline 
• 107-87-9 2-Pentanone 
• 67-64-1 acetone 
• 78-93-3 butanone 

Downstream Products

• 64398-14-7 8-chloromethyltheophylline 
• 4921-51-1 8-(hydroxymethyl)-1,3,7-trimethyl-3,7-dihydro-1H-purine-2,6-dione 
• 116589-31-2 8-Hydroxymethyl-1,3-dimethyl-7-((E)-3-phenyl-allyl)-3,7-dihydro-purine-2,6-dione 
• 116589-34-5 7-cinnamyl-8-bromomethyltheophylline 
• 116589-41-4 6,8-Dimethyl-3-phenyl-3a,4-dihydro-3H,8H,10H-1,2,4a,6,8,9,10a-heptaaza-cyclopenta[b]fluorene-5,7-dione 
• 109642-95-7 8-[(cyclohexyl-methyl-amino)-methyl]-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 
• 133231-18-2 8-[(N-ethyl-anilino)-methyl]-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 
• 100086-67-7 8-[(N-benzyl-anilino)-methyl]-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 
• 80999-75-3 8-[(3,4-Dimethyl-phenylamino)-methyl]-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 
• 80999-73-1 8-[(4-Bromo-phenylamino)-methyl]-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 
• 80999-74-2 8-[(4-Chloro-phenylamino)-methyl]-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 
• 81014-00-8 8-[(3-Chloro-phenylamino)-methyl]-1,3-dimethyl-3,7-dihydro-purine-2,6-dione 
• 81014-01-9 1,3-Dimethyl-8-(p-tolylamino-methyl)-3,7-dihydro-purine-2,6-dione 
• 80999-72-0 8-anilinomethyltheophylline 

Relevant academic research and scientific papers

SMALL MOLECULE ALDEHYDE DEHYDROGENASE INHIBITORS AND METHODS OF USE THEREOF

Described herein are compounds, salts and solvates of the formula (I). Certain compounds of formula (I) are potent and selective inhibitors of aldehyde dehydrogenases (ALDH), a family of enzymes that play a critical role in detoxification of various cytot

Discovery of NCT-501, a Potent and Selective Theophylline-Based Inhibitor of Aldehyde Dehydrogenase 1A1 (ALDH1A1)

Aldehyde dehydrogenases (ALDHs) metabolize reactive aldehydes and possess important physiological and toxicological functions in areas such as CNS, metabolic disorders, and cancers. Increased ALDH (e.g., ALDH1A1) gene expression and catalytic activity are vital biomarkers in a number of malignancies and cancer stem cells, highlighting the need for the identification and development of small molecule ALDH inhibitors. A new series of theophylline-based analogs as potent ALDH1A1 inhibitors is described. The optimization of hits identified from a quantitative high throughput screening (qHTS) campaign led to analogs with improved potency and early ADME properties. This chemotype exhibits highly selective inhibition against ALDH1A1 over ALDH3A1, ALDH1B1, and ALDH2 isozymes as well as other dehydrogenases such as HPGD and HSD17β4. Moreover, the pharmacokinetic evaluation of selected analog 64 (NCT-501) is also highlighted.

SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF

Compounds, compositions and methods are described for inhibiting the TRPC5 ion channel and disorders related to TRPC5.