81014-98-4

Basic information

• Product Name: 3,5-Pyridinedicarboxylic acid, 4-(4-hydroxyphenyl)-2,6-dimethyl-, diethyl ester
• CAS NO: 81014-98-4
• Molecular Formula: C19H21NO5
• Molecular Weight: 343.379
• Mol File: 81014-98-4.mol
• Article Data: 21

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarboxylic acid, 4-(4-hydroxyphenyl)-2,6-dimethyl-, diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarboxylic acid, 4-(4-hydroxyphenyl)-2,6-dimethyl-, diethyl ester(81014-98-4)
• EPA Substance Registry System: 3,5-Pyridinedicarboxylic acid, 4-(4-hydroxyphenyl)-2,6-dimethyl-, diethyl ester(81014-98-4)

Safety Data

• Hazardous Substances Data: 81014-98-4(Hazardous Substances Data)

Upstream product

• 838-57-3 ethyl 4-nitrobenzoylacetate 
• 141-97-9 ethyl acetoacetate 
• 123-08-0 4-hydroxy-benzaldehyde 
• 1694-31-1 tert-butyl acetoacetate 
• 1118-84-9 allyl acetoacetate 
• 5396-89-4 benzyl acetoacetate 
• 1479-24-9 ethyl 2-fluorobenzoylacetate 
• 126-81-8 dimedone 
• 105-45-3 acetoacetic acid methyl ester 
• 631-61-8 ammonium acetate 
• 10354-30-0 4-(4-hydroxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 

Relevant articles and documents

Silica-supported ceric ammonium nitrate (CAN): a simple, mild and solid-supported reagent for quickest oxidative aromatization of Hantzsch 1,4-dihydropyridines

An efficient and environmentally benign methodology for the oxidative aromatization of 1,4-dihydropyridines to their corresponding pyridine derivatives is developed. The oxidative aromatization of 1,4-dihydropyridines was explored using silica-supported ceric ammonium nitrate as catalyst in CH3CN with or without sonication at room temperature. This supported catalyst acts as a more efficient oxidising reagent and offers several advantages over other reported reagents in terms of reaction time and yields. The supported reagent is found to be more efficient and selective when compared with its unsupported form. The Belousov–Zhabotinskii reaction was not observed in present reaction. The dealkylation observed in case of 4-n-alkyl/n-alkenyl with other oxidising agents is also not observed in the present case.

Facile aromatisation of Hantzsch 1,4-dihydropyridines by autoxidation in the presence of p-toluenesulfonic acid in acetic acid

A simple protocol to achieve the aromatisation of Hantzsch dihydropyridines in high yield was established using p-toluenesulfonic acid in acetic acid and yields of 90% were obtained at room temperature. With regards to the Hantzsch 1,4-dihydropyridines derived from alkyl aldehydes bearing one or more á-hydrogens, dealkylation products were obtained through a proposed autoxidation mechanism.

A new oxidation system for the oxidation of Hantzsch-1,4-dihydropyridines and polyhydroquinoline derivatives under mild conditions

A new oxidation system (Na2S2O4/TBHP) to prepare pyridine derivatives has been developed by the oxidation of 1,4-dihydropyridine derivatives and polyhydroquinoline derivatives in good to excellent yields. The procedures of the reaction were green, convenient, mild and easy work-up.