81026-66-6Relevant academic research and scientific papers
Probing the frontiers of glycoprotein synthesis: The fully elaborated β-subunit of the human follicle-stimulating hormone
Nagorny, Pavel,Sane, Neeraj,Fasching, Bernhard,Aussedat, Baptiste,Danishefsky, Samuel J.
, p. 975 - 979 (2012)
Ambitious undertaking: The β-subunit of the human follicle-stimulating hormone (hFSH) displaying a N-linked consensus sequence oligosaccharide at each of the two wild-type sites was synthesized. The glycoprotein has been designed with acetamidomethyl prot
Enantioselective Synthesis of Quaternary Δ4- and Δ5-Dehydroprolines Based on a Two-Step Formal [3+2] Cycloaddition of α-Aryl and α-Alkyl Isocyano(thio)acetates with Vinyl Ketones
Odriozola, Amaiur,Oiarbide, Mikel,Palomo, Claudio
, p. 12758 - 12762 (2017/09/25)
A divergent synthesis of optically active quaternary Δ4- and Δ5-dehydro prolines is developed based on the first catalytic enantioselective conjugate addition of α-substituted isocyano(thio)acetates to vinyl ketones that is general for both α-aryl and α-alkyl isocyano(thio)acetates. The new tetrasubstituted C?N stereocenter is formed without the need of any metal salt due to a bifunctional tertiary amine/squaramide catalyst, featuring a bulky polyaryl sidearm and an unusually short squaramide diamide H???H interatomic distance in the solid state.
