81026-84-8

Basic information

• Product Name: (3aS,5R,6R,6aR)-6-Hydroxy-5-hydroxymethyl-2-oxo-tetrahydro-furo[2,3-d]oxazole-3-carboxylic acid benzyl ester
• Synonyms: (3aS,5R,6R,6aR)-6-Hydroxy-5-hydroxymethyl-2-oxo-tetrahydro-furo[2,3-d]oxazole-3-carboxylic acid benzyl ester
• CAS NO: 81026-84-8
• Molecular Weight: 309.276
• Mol File: 81026-84-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3aS,5R,6R,6aR)-6-Hydroxy-5-hydroxymethyl-2-oxo-tetrahydro-furo[2,3-d]oxazole-3-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (3aS,5R,6R,6aR)-6-Hydroxy-5-hydroxymethyl-2-oxo-tetrahydro-furo[2,3-d]oxazole-3-carboxylic acid benzyl ester(81026-84-8)
• EPA Substance Registry System: (3aS,5R,6R,6aR)-6-Hydroxy-5-hydroxymethyl-2-oxo-tetrahydro-furo[2,3-d]oxazole-3-carboxylic acid benzyl ester(81026-84-8)

Safety Data

• Hazardous Substances Data: 81026-84-8(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 27963-97-9 2-amino-(1,2-dideoxy-α-D-ribofurano)<1,2-d>-2-oxazoline 

Downstream Products

• 81026-82-6 2-Oxo-3-benzyloxycarbonyl-3',5'-di-O-benzoyl-α-D-ribofurano<1',2':4,5>-oxazolidin 
• 81002-71-3 (3aS,5R,6R,6aS)-6-Chloro-2-oxo-5-(toluene-4-sulfonyloxymethyl)-tetrahydro-furo[2,3-d]oxazole-3-carboxylic acid benzyl ester 
• 4554-10-3 (3aS)-6t-benzoyloxy-5c-benzoyloxymethyl-(3ar,6ac)-tetrahydro-furo[2,3-d]oxazol-2-one 
• 81026-81-5 2-Oxo-3-benzyloxycarbonyl-3',5'-di-O-acetyl-α-D-ribofurano<1',2':4,5>-oxazolidin 

Relevant articles and documents

Protected Aminooxazolines of Arabinose and Ribose

The reaction of D-arabinose or D-ribose with cyanamide afforded 2-amino-1,2-oxazolines 1 which were treated with dihydropyran or ethylvinylether.In the presence of PTS the 3',5'-di-THP- or 3',5'-di-O-ethoxyethyl-D-arabino-(ribo)-furo--2-oxazolines 2 and 3 could be isolated as useful intermediates for the preparation of nucleosides.When the 2-aminooxazolines are treated with benzyloxycarbonylchloride or its p-substituted derivatives the N-3 atom of the oxazoline ring is preferentially substituted.Under these conditions the exocyclic amino function is always replaced and 2-oxo-3-benzyloxycarbonylderivatives 4 are obtained; only traces of the corresponding 2-aminoderivatives 5 are formed.Treatment of 4 with acetic anhydride, benzoylchloride, and benzoylcyanide, respectively, results in the 3'-,5'-di-O-acylderivatives 6.Mild hydrolysis of the benzyloxycarbonyl group with trifluoroacetic acid yields the 3',5'-di-O-acyl-D-arabino-(ribo)-furo--2-oxooxazolidines as further intermediates for the synthesis of nucleosides.