81036-99-9Relevant academic research and scientific papers
Improved robust method for preparing optically active 3-alkyl-3-phenyl-1,4- dioxane-2,5-diones; A promising new chiral template
Nagase, Ryohei,Iida, Yuuki,Sugi, Mikiko,Misaki, Tomonori,Tanabe, Yoo
experimental part, p. 3670 - 3674 (2009/07/25)
A robust method for preparing (3S)-3-alkyl-3-phenyl-1,4-dioxane-2,5-diones was developed using an improved cyclocondensation reaction between (S)-α-alkylmandelic acids and 2-bromocarbonyl halides. Subtle differences in the reaction conditions, including separate additions of triethylamine, significantly increased the yield compared with Schollkopf s original method. Georg Thieme Verlag Stuttgart · New York.
SYNTHESIS OF ENANTIOMERICALLY ENRICHED ATROLACTIC ACID AND OTHER α-HYDROXY ACIDS
Frater, Gy.,Mueller, U.,Guenther, W.
, p. 4221 - 4224 (2007/10/02)
The α-anions of 2-substituted 1,3-dioxolan-4-ones derived from chiral mandelic and lattic acid (2a, 2b; 3a; 10a, 10b) were alkylated with high stereoselectivity, The products formed were hydrolysed to α-hydroxy acids with 65-85percent e.e. ((S)(+)-5,7,9, (R)(-)-13).
