81039-03-4Relevant academic research and scientific papers
Selectfluor mediated one pot synthesis of cyclohexanone ring fused isoxazole derivatives
Rajawinslin,Raihan, Mustafa J.,Janreddy, Donala,Kavala, Veerababurao,Kuo, Chun-Wei,Kuo, Ting-Shen,Chen, Mei-Ling,He, Chiu-Hui,Yao, Ching-Fa
, p. 7505 - 7510 (2014)
A Selectfluor and base mediated protocol for the synthesis of cyclohexanone ring fused isoxazole derivatives from isoxazoline N-oxides has been successfully developed. This rapid, one-pot, two-step transformation is achieved in acetonitrile, through nitroso intermediate followed by hydration, defluorination and N-O coupling in the presence of triethylamine. The scope and mechanism of the protocol have been demonstrated.
Effective synthesis of novel dihydrobenzisoxazoles bearing the 2-aminothiazole moiety and evaluation of the antiproliferative activity of their acylated derivatives
Khlebnicova, Tatyana S.,Lakhvich, Fedor A.,Matous, Anton E.,Piven, Yuri A.,Scherbakov, Alexander M.,Shchegolev, Yuri Yu.,Sorokin, Danila V.,Yastrebova, Margarita A.,Zinovich, Veronica G.
, p. 10432 - 10443 (2021/12/17)
An effective method for the synthesis of 8-aryl-4,5-dihydrothiazolo[4′,5′:3,4]benzo[1,2-c]isoxazol-2-amines was developed. This method includes the α-keto bromination of 3-aryl-6,7-dihydrobenzo[c]isoxazol-4(5H)-ones followed by the condensation of the obt
