81061-26-9Relevant academic research and scientific papers
Cobalt-Catalyzed Diastereo- And Enantioselective Reductive Allyl Additions to Aldehydes with Allylic Alcohol Derivatives via Allyl Radical Intermediates
Wang, Lei,Wang, Lifan,Li, Mingxia,Chong, Qinglei,Meng, Fanke
supporting information, p. 12755 - 12765 (2021/08/30)
Catalytic generation of ambiphilic π-allyl-metal complexes and their utility in enantioselective transformations constitutes a powerful approach for introduction of allyl groups to a molecule. Herein an unprecedented cobalt-catalyzed highly site-, diastereo-, and enantioselective protocol for stereoselective formation of nucleophilic allyl-Co(II) complexes followed by addition to aldehydes is presented. The reaction features diastereo- and enantioconvergent conversion of easily accessible allylic alcohol derivatives to diversified enantioenriched homoallylic alcohols with a remarkably broad scope of allyl groups that can be introduced. Mechanistic studies indicated that allyl radical intermediates were involved in this process. These new discoveries establish a new strategy for development of enantioselective transformations through capture of radicals by chiral Co complexes, pushing forward the frontier of Co complexes for enantioselective catalysis.
ALKYLATIVE ELIMINATIONS. CONJUGATED DIENECARBOXYLATES FROM (ETHOXYCARBONYLCYCLOPROPYL)CARBINYL ANIONS STABILIZED BY SULFUR GROUPS
Tomazic, A.,Ghera, E.
, p. 4349 - 4352 (2007/10/02)
(Ethoxycarbonylcyclopropyl)carbinyl anions stabilized by phenylsulfonyl or phenylthio groups undergo one-pot nucleophilic ring fission, alkylation and elimination of the sulfur function to give substituted dienoates or dienedioates.
