81066-92-4Relevant articles and documents
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines
Fallacara, Anna Lucia,Passannanti, Raffaele,Mori, Mattia,Iovenitti, Giulia,Musumeci, Francesca,Greco, Chiara,Crespan, Emmanuele,Kissova, Miroslava,Maga, Giovanni,Tarantelli, Chiara,Spriano, Filippo,Gaudio, Eugenio,Bertoni, Francesco,Botta, Maurizio,Schenone, Silvia
, (2019/08/12)
Abnormal activation of B-cell receptor (BCR) signaling plays a key role in the development of lymphoid malignancies, and could be reverted by the simultaneous inhibition of Lyn, Fyn and Blk, three members of the Src family kinase (SFK). Fyn and Blk are al
