81066-92-4Relevant academic research and scientific papers
Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines
Fallacara, Anna Lucia,Passannanti, Raffaele,Mori, Mattia,Iovenitti, Giulia,Musumeci, Francesca,Greco, Chiara,Crespan, Emmanuele,Kissova, Miroslava,Maga, Giovanni,Tarantelli, Chiara,Spriano, Filippo,Gaudio, Eugenio,Bertoni, Francesco,Botta, Maurizio,Schenone, Silvia
, (2019/08/12)
Abnormal activation of B-cell receptor (BCR) signaling plays a key role in the development of lymphoid malignancies, and could be reverted by the simultaneous inhibition of Lyn, Fyn and Blk, three members of the Src family kinase (SFK). Fyn and Blk are al
One-pot synthesis of tetrasubstituted pyrazoles - Proof of regiochemistry
Hanefeld, Ulf,Rees, Charles W.,White, Andrew J. P.,Williams, David J.
, p. 1545 - 1552 (2007/10/03)
1-Alkyl-5-amino-3-aryl-4-cyanopyrazoles, useful intermediates for fused heterocyclic systems, are synthesised by a one-pot three-step procedure from acid chlorides, malononitrile and alkylhydrazines. The regiochemistry of the hydrazine incorporation was p
