810672-01-6

Upstream product

• 13156-95-1 2-chloro-N-phenethylacetamide 
• 222555-06-8 ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate 
• 112725-03-8 N-acetyl-N-chloro-2-phenethylamine 

Relevant academic research and scientific papers

TRI (HYDROXYMETHYL) METHYLAMINE SALT OR AN ETHANOL AMINE SALT OF (2S) -2-ETHOXY-3- (4-{2- [HEXYL (2- PHENYLETHYL) AMINO] - 2 -OXOETHOXY} PHENYL) PROPANOIC ACID

The invention relates to a compound selected from one or more of the following: a tris (hydroxymethyl) methylamine salt of (2S)-2- ethoxy-3-(4-{2- [hexyl (2-phenylethyl) amino]-2- oxoethoxy} phenyl) propanoic acid; an ethanol amine salt of (2S)-2-ethoxy-3- (4-{2-[hexyl (2-phenylethyl) amino]-2-oxoethoxy} phenyl) propanoic acid; or a pharmaeutical composition comprising the compound.

PROCESSES FOR PREPARING (2S)-3-(4-{2-[AMINO]-2-OXOETHOXY}PHENYL)-2-ETHOXYPROPANOIC ACID DERIVATIVES

The present invention provides a process for the preparation of a compound of formula I [Chemical formula should be inserted here. Please see paper copy] in which a compound of formula II [Chemical formula should be inserted here. Please see paper copy] in which R is H or OR represents a protecting group for a carboxylic hydroxy group is reacted with a compound of formula III C6H13X wherein X is a leaving group, in the presence of a base in the presence of an inert solvent at a temperature in the range -25°C to 150°C and optionally, when OR represents a protecting group, removal of the protecting group.

PHARMACEUTICALLY USEFUL SALTS OF CARBOXYLIC ACID DERIVATES

A calcium or a magnesium salt of (2S)-2-ethoxy-3-(4-{2[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid.

PHARMACEUTICALLY USEFUL SALTS OF CARBOXYLIC ACID DERIVATES

A compound selected from one or more of the following: a ( 1R,2S)-2-hydroxyindan-1-amine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an L-arginine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a tert-butylamine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a choline salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an adamantylamine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; a N-benzyl-2-phenylethanaminium salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; aN-benzyl-2-(benzylamino) ethanaminium salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; or a tris(hydroxymethyl)methylamine salt of (2S)-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid.