112725-03-8

Basic information

• Product Name: Acetamide, N-chloro-N-(2-phenylethyl)-
• CAS NO: 112725-03-8
• Molecular Formula: C10H12ClNO
• Molecular Weight: 197.664
• Mol File: 112725-03-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Acetamide, N-chloro-N-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-chloro-N-(2-phenylethyl)-(112725-03-8)
• EPA Substance Registry System: Acetamide, N-chloro-N-(2-phenylethyl)-(112725-03-8)

Safety Data

• Hazardous Substances Data: 112725-03-8(Hazardous Substances Data)

Upstream product

• 64-04-0 phenethylamine 
• 79-04-9 chloroacetyl chloride 
• 877-95-2 methyl-N-(benzyl-methyl)-formamide 

Downstream Products

• 15987-50-5 1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one 
• 810672-01-6 ethyl (2S)-2-ethoxy-3-(4-{2-oxo-2-[(2-phenylethyl)amino]-ethoxy}phenyl)propanoate 

Relevant articles and documents

PROCESSES FOR PREPARING (2S)-3-(4-{2-[AMINO]-2-OXOETHOXY}PHENYL)-2-ETHOXYPROPANOIC ACID DERIVATIVES

The present invention provides a process for the preparation of a compound of formula I [Chemical formula should be inserted here. Please see paper copy] in which a compound of formula II [Chemical formula should be inserted here. Please see paper copy] in which R is H or OR represents a protecting group for a carboxylic hydroxy group is reacted with a compound of formula III C6H13X wherein X is a leaving group, in the presence of a base in the presence of an inert solvent at a temperature in the range -25°C to 150°C and optionally, when OR represents a protecting group, removal of the protecting group.

Benzazepine derivatives, their pharmaceutical compositions and method of use

Compounds of the formula STR1 wherein A is --CH2 --CH2 --, --CH=CH--, --NH--CO--, --CH2 --CO-- or STR2 where R7 is alkyl of 1 to 3 carbon atoms, and B is methylene, carbonyl or thiocarbonyl, or A is --CO--CO--, --N=CH--, STR3 where R8 is hydrogen or alkyl of 1 to 3 carbon atoms substituted by a phenyl, methoxyphenyl or dimethoxyphenyl, and B is methylene; E is n-alkylene of 2 to 4 carbon atoms optionally substituted by an alkyl of 1 to 3 carbon atoms, 2-hydroxy-n-propylene, 2-hydroxy-n-butylene or 3-hydroxy-n-butylene; G is n-alkylene of 1 to 5 carbon atoms optionally substituted by an alkyl of 1 to 3 carbon atoms, wherein one methylene group of an n-alkylene of 2 to 5 carbon atoms can be replaced by a carbonyl group, with the proviso that B represents a methylene or carbonyl group, or methylene-n-hydroxy-alkylene of 1 to 4 carbon atoms, where the methylene group is attached to the nitrogen atom; and R1 to R5 are simple substituents of various types; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.