810677-19-1

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 141-82-2 malonic acid 
• 105-13-5 4-Methoxybenzyl alcohol 
• 926-71-6 dipotassium malonate 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 760952-54-3 bis(4-methoxybenzyl) 3-tert-butyldimethylsiloxycyclobutane-1,1-dicarboxylate 
• 151630-83-0 (6R-trans)-3-<<6-(2-benzhydryloxycarbonyl-5,8-dioxo-7-phenylacetylamino-5-thia-1-azabicyclo<4.2.0>oct-2-en-3-yl)methoxycarbonyl>hexyl>cyclobutane-1,1-dicarboxylic acid bis(p-methoxybenzyl) ester 
• 151630-84-1 (6R-trans)-3-<<6-(2-benzhydryloxycarbonyl-8-oxo-7-phenylacetylamino-5-thia-1-azabicyclo<4.2.0>oct-2-en-3-yl)methoxycarbonyl>hexyl>cyclobutane-1,1-dicarboxylic acid bis(p-methoxybenzyl) ester 
• 151630-81-8 3-(6-carboxyhexyl)cyclobutane-1,1-dicarboxylic acid bis(p-methoxybenzyl) ester 
• 151630-80-7 3-(oct-7-enyl)cyclobutane-1,1-dicarboxylic acid bis(p-methoxybenzyl) ester 

Relevant academic research and scientific papers

Allyl 4-Chlorophenyl Sulfone as a Versatile 1,1-Synthon for Sequential α-Alkylation/Cobalt-Catalyzed Allylic Substitution

Despite their unique potential as rare 1,1-dipole synthons, allyl sulfones are rarely used in target-oriented syntheses, likely due to the lack of a general catalytic method for their branch-selective allylic substitution. Herein, we identified allyl 4-chlorophenyl sulfone as a versatile linchpin for both base-mediated α-derivatization and subsequent cobalt-catalyzed allylic substitution. The sequential transformations allow for highly regioselective access to branched allylic substitution products with a variety of aliphatic side chains. The photoredox-enabled cobalt catalysis is indispensable for achieving high yields and regioselectivity for the desulfonylative substitution in contrast to traditional metal-catalyzed protocols, which lead to inferior outcomes in the corresponding transformations.

Thiourea-Catalyzed Enantioselective Malonate Addition onto 3-Sulfonyl-3′-indolyl-2-oxindoles: Formal Total Syntheses of (-)-Chimonanthine, (-)-Folicanthine, and (+)-Calycanthine

A general approach to bispyrroloindolines via a key thiourea-catalyzed addition of malonates to 3-sulfonyl-3′-indolyl-2-oxindoles is reported. The enantioselelective process is found to be highly effective (up to 94% ee), where a C-C bond formation leads