81069-40-1Relevant articles and documents
Trans-cinnamic acid ester compound and its synthetic method and application
-
Paragraph 0071; 0072, (2016/10/07)
The invention relates to a trans cinnamic acid ester compound, as well as a synthetic method and application thereof. At present, a typic miticide has the growing problems, such as drug resistance and environment and ecology, so that a new animal miticide needs to be developed very urgently. The trans cinnamic acid ester compound has the molecular structure shown in the specification, wherein R refers to alkyl radical, R1 and R2 refer to hydrogen, hydroxide radical, alkyl radical, alkoxy, fatty acyloxy, halogen, methylenedioxy or nitro, and are the same or different; the trans cinnamic acid ester compound can be used for preparing miticides for animals and people. The compound serves as a novel miticide, is relatively low in toxicity, small in molecular weight, few in synthetic steps, simple to operate, low in production cost, and suitable for large-scale industrial production; the acaricidal activity is remarkably stronger that of a miticide applied in current all clinics.
A general model for selectivity in olefin cross metathesis
Chatterjee, Arnab K.,Choi, Tae-Lim,Sanders, Daniel P.,Grubbs, Robert H.
, p. 11360 - 11370 (2007/10/03)
In recent years, olefin cross metathesis (CM) has emerged as a powerful and convenient synthetic technique in organic chemistry; however, as a general synthetic method, CM has been limited by the lack of predictability in product selectivity and stereoselectivity. Investigations into olefin cross metathesis with several classes of olefins, including substituted and functionalized styrenes, secondary allylic alcohols, tertiary allylic alcohols, and olefins with α-quaternary centers, have led to a general model useful for the prediction of product selectivity and stereoselectivity in cross metathesis. As a general ranking of olefin reactivity in CM, olefins can be categorized by their relative abilities to undergo homodimerization via cross metathesis and the susceptibility of their homodimers toward secondary metathesis reactions. When an olefin of high reactivity is reacted with an olefin of lower reactivity (sterically bulky, electron-deficient, etc.), selective cross metathesis can be achieved using feedstock stoichiometries as low as 1:1. By employing a metathesis catalyst with the appropriate activity, selective cross metathesis reactions can be achieved with a wide variety of electron-rich, electron-deficient, and sterically bulky olefins. Application of this model has allowed for the prediction and development of selective cross metathesis reactions, culminating in unprecedented three-component intermolecular cross metathesis reactions.
THE PALLADIUM-CATALYSED ARYLATION OF ACTIVATED ALKENES WITH AROYL CHLORIDES
Blaser, Hans-Ulrich,Spencer, Alwyn
, p. 267 - 274 (2007/10/02)
Aroyl chlorides react with activated alkenes in presence of a tertiary amine and a catalytic amount of palladium acetate to give arylated alkenes, specifically cinnamic acid derivatives and stilbenes.The reaction involves a highly efficient decarbonylation of the aroyl chloride.High yields can be obtained at low catalyst concentration by choice of an appropriate base.The reaction is not particularly sensitive to substituents in the aroyl chloride, although strongly electron-donating groups are advantagenous (yields up to 98percent).With monosubstituted alkenes E-isomers are formed with almost complete specificity.A mechanism for the reaction is proposed.
