81076-36-0Relevant academic research and scientific papers
Practical synthesis of 2,5-disubstituted 1,3-dioxolane-4-ones and highly diastereoselective cis-2,5-disubstituted 1,3-dioxolane-4-ones from α-hydroxy acids catalyzed by N-triflylphosphoramide
Kü?ük, Hatice Ba?pinar
, p. 5583 - 5586 (2015)
N-triflylphosphoramide (NTPA) was found to be an efficient Br?nsted acid catalyst for the practical synthesis of 2,5-disubstituted 1,3-dioxolane-4-ones. Racemic and optically pure mandelic acid and lactic acid could be protected using several aldehydes in
SYNTHESIS OF ENANTIOMERICALLY ENRICHED ATROLACTIC ACID AND OTHER α-HYDROXY ACIDS
Frater, Gy.,Mueller, U.,Guenther, W.
, p. 4221 - 4224 (2007/10/02)
The α-anions of 2-substituted 1,3-dioxolan-4-ones derived from chiral mandelic and lattic acid (2a, 2b; 3a; 10a, 10b) were alkylated with high stereoselectivity, The products formed were hydrolysed to α-hydroxy acids with 65-85percent e.e. ((S)(+)-5,7,9, (R)(-)-13).
