81077-30-7Relevant academic research and scientific papers
In Vitro Antiviral Activity of New Oxazoline Derivatives as Potent Poliovirus Inhibitors
Madia, Valentina Noemi,Messore, Antonella,Pescatori, Luca,Saccoliti, Francesco,Tudino, Valeria,De Leo, Alessandro,Scipione, Luigi,Fiore, Lucia,Rhoden, Eric,Manetti, Fabrizio,Oberste, M. Steven,Di Santo, Roberto,Costi, Roberta
, p. 798 - 810 (2019)
The final stages of polio eradication are proving more difficult than the early phases, and the development of effective drugs and treatments is considered a priority; thus, the research is ongoing. A screening of our in-house chemical library against poliovirus Sabin strains led to the identification of compounds 5 and 6 as hits active at submicromolar concentrations. Derivatives of these compounds were synthesized as a preliminary structure-activity-relationship study. Among them, 7 and 11 were highly active against poliovirus Sabin 1-3. Compound 11 was also very potent against a large panel of wild and vaccine-derived polioviruses. Time-of-addition experiments suggest that 5 and 7 could be active at an early stage of viral replication, whereas 11 was active at same concentration at all stages of viral replication. A ligand-based approach was applied to find the common structural features shared by the new compounds and already-known poliovirus inhibitors.
Phenyl amidines derivatives useful as platelet aggregation inhibitors
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, (2008/06/13)
This invention relates to phenyl amidine derivatives having the following formula STR1 or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phe
TRANS STEREOSELECTIVITY IN THE REACTION OF (4-CARBOXYBUTYLIDENE)TRIPHENYLPHOSPHORANE WITH AROMATIC ALDEHYDES
Maryanoff, Bruce E.,Duhl-Emswiler, Barbara A.
, p. 4185 - 4188 (2007/10/02)
Aromatic aldehydes react with 1 to give predominantly trans 6-aryl-5-hexenoic acids, under special conditions.A systematic study of the reaction of 1 with aldehydes, in a preliminary attempt to define the cause and scope of the trans stereoselectivity, is reported.
