81085-78-1

Upstream product

• 98-79-3 L-Pyroglutamic acid 
• 17337-68-7 N^α-Benzyloxycarbonyl-lysyl(N^ε-t-butyloxycarbonyl)phenylalaninamide 
• 5241-56-5 benzyl [(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamate 
• 2389-60-8 Z-Lys(Boc)-OH 
• 5241-58-7 L-Phenylalanine amide 
• 17337-86-9 H-Lys(Boc)Phe-NH₂ 

Downstream Products

• 97327-31-6 Glp-Lys-gPhe-(S)-mAla-Pro-OH 
• 97327-31-6 Glp-Lys-gPhe-(R)-mAla-Pro-OH 
• 97327-28-1 Glp-Lys(Boc)-gPhe-(S)-mAla-Pro-OtBu 
• 97327-28-1 Glp-Lys(Boc)-gPhe-(R)-mAla-Pro-OtBu 
• 97327-26-9 Glp-Lys(Boc)-gPhe-H*HCl 

Relevant academic research and scientific papers

Synthesis, Resolution, and Assignment of Configuration of Potent Hypotensive Retro-inverso Bradykinin Potentiating Peptide 5a(BPP5a) Analogues

The effect on the the biological activity of an inverted amide group as an isosteric replacement for the Phe-Ala scissile bond of the BPP5a analogue 3>BPP5a has been studied.The synthesis of the retro-inverso pentapeptide 3,(R,S)-mAla4>BPP5a has been carried out in solution by coupling the pseudopeptide epimer HO-(R,S)-mAla-Pro-OBut to Glp-Lys(Boc)-gPhe-H.HCl, separation and identification of the resulting diastereomers 2(Boc),gPhe3,(S)-mAla4,Pro5-OBut>BPP5a and 2(Boc),gPhe3,(R)-mAla4,Pro5-OBut>BPP5a, and finally acidolytic cleavage. 3,(S)-mAla4>BPP5a, a moderate inhibitor of angiotensin converting enzyme (ACE) in vitro (I50=14 x 1E-5), was obtained and proved to be more potent than BPP5a as a hypotensive in normotensive rats without manifesting the bradykinin potentiating action of the natural peptide.