81097-18-9Relevant academic research and scientific papers
SYNTHESIS OF MONOCYCLIC ANALOGUES OF A POTENT THROMBOXANE RECEPTOR ANTAGONIST, (+/-)-(5Z)-7-BICYCLOHEPT-2-EXO-YL>HEPTENOIC ACID (S-145)
Kawada, Kenji,Tsushima, Tadahiko
, p. 573 - 578 (2007/10/02)
Several monocyclic analogues of the potent thromboxane-A2 receptor antagonist S-145, i.e. cyclohexane, cyclopentane, tetrahydrofuran, and pyrrolidine, as well as the biclooctane one were synthesized using allylation via oxime dianion and the Barton's method for oxime reduction in the key steps.
Palladium-Catalyzed Cyclization of ω-Olefinic Tosamides. Synthesis of Nonaromatic Nitrogen Heterocycles
Hegedus, Louis S.,McKearin, James M.
, p. 2444 - 2451 (2007/10/02)
The cyclization of aliphatic amino olefins to nonaromatic nitrogen heterocycles nas been accomplished by conversion of the amine to the corresponding p-toluenesulfonamide, followed by Pd(II)-catalyzed intramolecular amination of the olefin.The resulting t
